Journal ArticleDOI
Altered gut microbiota and intestinal permeability in Parkinson's disease: Pathological highlight to management.
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TLDR
Mechanistic approach for gut associated PD symptoms as well as use of probiotics and prebiotics as therapeutic approach to retain gut microbial flora and prevent PD like symptoms are explored.About:
This article is published in Neuroscience Letters.The article was published on 2019-11-01. It has received 19 citations till now. The article focuses on the topics: Intestinal permeability & Gut–brain axis.read more
Citations
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Journal ArticleDOI
Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions.
TL;DR: This work summarizes the known ultrastructural, molecular, and functional features of direct microglia-neuron interactions and their roles in brain disease.
Journal ArticleDOI
Potential roles of gut microbiota and microbial metabolites in Parkinson's disease.
Shen-Yuan Zheng,Hai-Xia Li,Rui-Chen Xu,Wen-Teng Miao,Ming-Yuan Dai,Song-Tao Ding,Han-Deng Liu +6 more
TL;DR: Parkinson's disease (PD) is a complicated neurodegenerative disease attributed to multifactorial changes as discussed by the authors, however, its pathological mechanism remains undetermined, and the authors of this review explored alterations to gut microbiota, correlations with clinical manifestations of PD, and briefly probes the underlying mechanisms.
Journal ArticleDOI
The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?
TL;DR: In this article, a large and expending body of evidence indicates that the gut-brain axis likely plays a crucial role in neurological diseases, including multiple sclerosis (MS), as a whole, the pathway can be considered as a bi-directional multi-crosstalk pathway that governs the interaction between the microbiota and the organism.
Journal ArticleDOI
Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions
Duygu Ağagündüz,Feray Gencer-Bingol,Elif Çelik,Özge Cemali,Çiler Özenir,Fatih Özogul,Raffaele Capasso +6 more
TL;DR: In this article , the authors discuss the role of probiotics in the pathogenesis of diseases that age day by day in the modern world via the gut-brain axis, and discuss the novel roles of LBPs in some gut brain axis related conditions in light of recent studies.
Journal ArticleDOI
Spectrum of Non-Motor Symptoms in Parkinson's Disease.
TL;DR: Parkinson's disease is predominantly classified as a movement disorder Beyond the textbook definition of rigidity, tremors, and bradykinesia, Parkinson's disease encompasses an entire entity of non-motor symptom complexes that can precede the motor features by many years as mentioned in this paper.
References
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Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
Enterotypes of the human gut microbiome
Manimozhiyan Arumugam,Jeroen Raes,Eric Pelletier,Denis Le Paslier,Takuji Yamada,Daniel R. Mende,Gabriel Fernandes,Julien Tap,Thomas Brüls,Jean-Michel Batto,Marcelo Bertalan,Natalia Borruel,Francesc Casellas,Leyden Fernández,Laurent Gautier,Torben Hansen,Masahira Hattori,Tetsuya Hayashi,Michiel Kleerebezem,Ken Kurokawa,Marion Leclerc,Florence Levenez,Chaysavanh Manichanh,H. Bjørn Nielsen,Trine Nielsen,Nicolas Pons,Julie Poulain,Junjie Qin,Thomas Sicheritz-Pontén,Sebastian Tims,David Torrents,Edgardo Ugarte,Erwin G. Zoetendal,Jun Wang,Francisco Guarner,Oluf Pedersen,Willem M. de Vos,Søren Brunak,Joël Doré,Jean Weissenbach,S. Dusko Ehrlich,Peer Bork +41 more
TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.
Journal ArticleDOI
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
Journal Article
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
TL;DR: This review summarizes the available evidence supporting the existence of microbiota-GBA interactions, as well as the possible pathophysiological mechanisms involved, and describes the importance of gut microbiota in influencing these interactions.
Journal ArticleDOI
Gut microbiota are related to Parkinson's disease and clinical phenotype.
Filip Scheperjans,Velma T. E. Aho,Pedro A. B. Pereira,Kaisa Koskinen,Lars Paulin,Eero Pekkonen,Elena Haapaniemi,Seppo Kaakkola,Johanna Eerola-Rautio,Marjatta Pohja,Esko Kinnunen,Kari Murros,Petri Auvinen +12 more
TL;DR: The findings suggest that the intestinal microbiome is altered in PD and is related to motor phenotype, and the suitability of the microbiome as a biomarker is warranted.