Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure
Milton Packer,John J.V. McMurray,Akshay S. Desai,Jianjian Gong,Martin Lefkowitz,Adel R. Rizkala,Jean L. Rouleau,Victor Shi,Scott D. Solomon,Karl Swedberg,Michael R. Zile,Karl Andersen,Juan Luis Arango,J. Malcolm O. Arnold,Jan Belohlavek,Michael Böhm,Sergey Boytsov,Lesley J. Burgess,Walter Cabrera,Carlos Calvo,Chen Huan Chen,Andrej Dukát,Yan Carlos Duarte,Andrejs Erglis,Michael Fu,Efrain Gomez,Angel Gonzàlez-Medina,Albert A. Hagège,Jun Huang,Tzventana Katova,Songsak Kiatchoosakun,Kee-Sik Kim,Ömer Kozan,Edmundo Alfredo Bayram Llamas,Felipe Martinez,Béla Merkely,Ivan Mendoza,Arend Mosterd,Marta Negrusz-Kawecka,Keijo Peuhkurinen,Felix José Alvarez Ramires,Jens Refsgaard,Arvo Rosenthal,Michele Senni,Antonio S. Sibulo,José Silva-Cardoso,Iain B. Squire,Randall C. Starling,John R. Teerlink,Johan Vanhaecke,Dragos Vinereanu,Raymond Ching-Chiew Wong +51 more
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TLDR
Angiotensin-neprilysin inhibition prevents the clinical progression of surviving patients with heart failure more effectively than angiotens in-converting enzyme inhibition.Abstract:
Background—Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs ...read more
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Journal ArticleDOI
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Monica Colvin,Mark H. Drazner,Gerasimos Filippatos,Gregg C. Fonarow,Michael M. Givertz,Steven M. Hollenberg,JoAnn Lindenfeld,Frederick A. Masoudi,Patrick E. McBride,Pamela N. Peterson,Lynne W. Stevenson,Cheryl Westlake +16 more
TL;DR: The next generation of leaders in the field of FACC/FAHA education and training will be shaped by the experiences of the past 50 years, which will help shape the future of the profession.
Journal ArticleDOI
2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure
Clyde W. Yancy,Mariell Jessup,Biykem Bozkurt,Javed Butler,Donald E. Casey,Monica Colvin,Mark H. Drazner,Gerasimos Filippatos,Gregg C. Fonarow,Michael M. Givertz,Steven M. Hollenberg,JoAnn Lindenfeld,Frederick A. Masoudi,Patrick E. McBride,Pamela N. Peterson,Lynne W. Stevenson,Cheryl Westlake +16 more
TL;DR: Biykem Bozkurt, MD, PHD, FACC, FAHA*y Javed Butler,MD, MBA, MPH, F ACC,FAHA*z Donald E. Casey, JR, MD; Monica M.Casey, JR; and Cheryl Westlake,PHD, RN, ACNS-BC, FAha, FHFSA.
Journal ArticleDOI
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets.
Yow Keat Tham,Yow Keat Tham,Bianca C. Bernardo,Jenny Y. Y. Ooi,Kate L. Weeks,Julie R. McMullen,Julie R. McMullen +6 more
TL;DR: New therapeutic approaches either entering clinical trials or in preclinical development, and the challenges that remain in translating these discoveries to new and approved therapies for heart failure are addressed.
Journal ArticleDOI
Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children
Kara Nerenberg,Kelly B. Zarnke,Alexander A. Leung,Kaberi Dasgupta,Sonia Butalia,Kerry McBrien,Kevin C. Harris,Meranda Nakhla,Lyne Cloutier,Mark Gelfer,Maxime Lamarre-Cliche,Alain Milot,Peter Bolli,Guy Tremblay,Donna McLean,Raj Padwal,Karen C. Tran,Steven A. Grover,Simon W. Rabkin,Gordon W. Moe,Jonathan G. Howlett,Patrice Lindsay,Michael D. Hill,Mike Sharma,Thalia S. Field,Theodore Wein,Ashkan Shoamanesh,George K. Dresser,Pavel Hamet,Robert J. Herman,Ellen Burgess,Steven E. Gryn,Jean Grégoire,Richard Lewanczuk,Luc Poirier,Tavis S. Campbell,Ross D. Feldman,Kim L. Lavoie,Ross T. Tsuyuki,George Honos,Ally P.H. Prebtani,Gregory A. Kline,Ernesto L. Schiffrin,Andrew C. Don-Wauchope,Sheldon W. Tobe,Richard E. Gilbert,Lawrence A. Leiter,Charlotte Jones,Vincent Woo,Robert A. Hegele,Peter Selby,Andrew L. Pipe,Philip A. McFarlane,Paul Oh,Milan Gupta,Simon L. Bacon,Janusz Kaczorowski,Luc Trudeau,Norman R.C. Campbell,Swapnil Hiremath,Michael Roerecke,JoAnne Arcand,Marcel Ruzicka,G. V. Ramesh Prasad,Michel Vallée,Cedric Edwards,Praveena Sivapalan,S. Brian Penner,Anne Fournier,Geneviève Benoit,Janusz Feber,Janis M. Dionne,Laura A. Magee,Alexander G. Logan,Anne-Marie Côté,Evelyne Rey,Tabassum Firoz,Laura M. Kuyper,Jonathan Y. Gabor,Raymond R. Townsend,Doreen M. Rabi,Doreen M. Rabi,Stella S. Daskalopoulou +82 more
TL;DR: All individuals with hypertension should have an assessment of global cardiovascular risk to promote health behaviours that lower blood pressure, and an angiotensin receptor-neprilysin inhibitor combination should be used in place of either an ang Elliotensin-converting enzyme inhibitor or angiotENSin receptor blocker in individuals with heart failure.
Journal ArticleDOI
2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure.
Justin A. Ezekowitz,Eileen O'Meara,Michael McDonald,Howard Abrams,Michael Chan,Anique Ducharme,Nadia Giannetti,Adam Grzeslo,Peter G. Hamilton,George A. Heckman,Jonathan G. Howlett,Sheri L. Koshman,Serge Lepage,Robert S. McKelvie,Gordon W. Moe,Miroslaw Rajda,Elizabeth Swiggum,Sean A. Virani,Shelley Zieroth,Abdul Al-Hesayen,Alain Cohen-Solal,Michel D'Astous,Sabe De,Estrellita Estrella-Holder,Stephen E. Fremes,Lee A. Green,Haissam Haddad,Karen Harkness,Adrian F. Hernandez,Simon Kouz,Marie Helene LeBlanc,Frederick A. Masoudi,Heather J. Ross,Andre Roussin,Bruce Sussex +34 more
TL;DR: The 2017 HF guidelines provide updated guidance on the diagnosis and management that should aid in day-to-day decisions for caring for patients with HF, with attention to strategies and treatments to prevent HF, to the organization of HF care, comorbidity management, as well as practical issues around the timing of referral and follow-up care.
References
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Journal ArticleDOI
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
Journal ArticleDOI
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.
TL;DR: The addition of enalapril to conventional therapy significantly reduced mortality and hospitalizations for heart failure in patients with chronic congestive heart failure and reduced ejection fractions.
Journal ArticleDOI
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
Journal ArticleDOI
Angiotensin-neprilysin inhibition versus enalapril in heart failure.
John J.V. McMurray,Milton Packer,Akshay S. Desai,Jianjian Gong,Martin Lefkowitz,Adel R. Rizkala,Jean L. Rouleau,Victor Shi,Scott D. Solomon,Karl Swedberg,Michael R. Zile,Abstr Act +11 more
TL;DR: LCZ696 was superior to enalapril in reducing the risks of death and of hospitalization for heart failure and decreased the symptoms and physical limitations of heart failure.
Journal ArticleDOI
Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
Karl Swedberg,John Kjekshus +1 more
TL;DR: The addition of enalapril to conventional therapy in patients with severe congestive heart failure can reduce mortality and improve symptoms, and the effect seems to be due to a reduction in death from progression of heart failure.
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