Journal ArticleDOI
Anti-hypernociceptive and anti-inflammatory effects of JM-20: A novel hybrid neuroprotective compound.
Bárbara B. Garrido-Suárez,Gabino Garrido,Marian Castro-Labrada,Nelson Merino,Odalys Valdés,Zenia Pardo,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,René Delgado-Hernández,Jozi Godoy-Figueiredo,Sérgio H. Ferreira +10 more
TLDR
The findings of this study suggest JM-20 can decrease persistent pain and a transient activity of its BDZ portion on nociceptive pathways mediated by GABA/BZD receptors in association with its anti-inflammatory properties could be at least partially involved in this effect.About:
This article is published in Brain Research Bulletin.The article was published on 2020-12-01. It has received 3 citations till now. The article focuses on the topics: Hyperalgesia & Nitric oxide.read more
Citations
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Journal ArticleDOI
SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.
Orest Tsymbalyuk,Volodymyr Gerzanich,Aaida Mumtaz,Sanketh Andhavarapu,Svetlana Ivanova,Tapas K. Makar,Charles A. Sansur,Asaf Keller,Yumiko Nakamura,Joseph Bryan,J. Marc Simard +10 more
TL;DR: In this paper, the salutary effects of glibenclamide on pain behaviors correlated with reduced expression of IL-6, CCL2 and CXCL1 by dorsal horn astrocytes.
Journal ArticleDOI
JM-20 affects GABA neurotransmission in Caenorhabditis elegans.
Aline Franzen da Silva,Larissa Marafiga Cordeiro,Marcell Valandro Soares,Danielle Coradini Zamberlan,Fabiane Bicca Obetine Baptista,Tássia Limana da Silveira,Marina Lopes Machado,Leticia Priscilla Arantes,Yanier Nuñez-Figueredo,Estael Ochoa Rodríguez,Félix Alexandre Antunes Soares +10 more
TL;DR: In this paper , the effects of chronic treatment with JM-20 on the C. elegans GABAergic system were investigated and the results showed that JM-21 does not cause mortality, but higher concentrations can delay the development of worms after 48 h exposure.
Journal ArticleDOI
3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance
Sisa Chalán-Gualán,Vida Castro,Ruth Alejandra Oropeza,Margarita Suarez,Fernando Albericio,Hortensia Rodríguez +5 more
TL;DR: Additional to the conventional multicomponent synthesis of the mentioned heterocycle, nonconventional procedures are revised, demonstrating the increasing efficiency and allowing reactions to be carried out in the absence of the solvent, becoming an important contribution to green chemistry.
References
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Journal ArticleDOI
Quantitative assessment of tactile allodynia in the rat paw.
TL;DR: Threshold measurement using the up-down paradigm, in combination with the neuropathy pain model, represents a powerful tool for analyzing the effects of manipulations of the neuropathic pain state.
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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.
Gary J. Bennett,Y.-K. Xie +1 more
TL;DR: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve and the postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain were produced.
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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal Article
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
Journal ArticleDOI
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
TL;DR: The major triggers that initiate and maintain central sensitization in healthy individuals in response to nociceptor input and in patients with inflammatory and neuropathic pain are reviewed, emphasizing the fundamental contribution and multiple mechanisms of synaptic plasticity caused by changes in the density, nature, and properties of ionotropic and metabotropic glutamate receptors.