Journal ArticleDOI
Antioxidant effects of black rice extract through the induction of superoxide dismutase and catalase activities
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TLDR
The ex vivo study revealed that BRE had significantly stronger ability to inhibit LDL oxidation than white rice extract (WRE) and antioxidative effects exerted by BRE are mediated through decreases in free-radical generation as well as increases in SOD and CAT activities both in vitro and in vivo.Abstract:
Our ex vivo study revealed that BRE had significantly stronger ability to inhibit LDL oxidation than white rice extract (WRE). The purpose of this study was to investigate whether black rice extract (BRE) supplementation might ameliorate oxidative stress and enhance antioxidant enzyme activities in HepG2 cells and in C57BL/6 mice. In the cellular study, superoxide anions (O2.−) and reactive oxygen species (ROS) in the BRE group were significantly suppressed. The BRE group also showed significant increases in superoxide dismutase (SOD) and catalase (CAT) activities by 161.6% and 73.4%, respectively. The major components responsible for the free-radical-scavenging and antioxidative properties might be cyanidin−3-O-glucoside chloride and peonidin-3-O-glucuside chloride. In the animal study, male C57BL/6 mice were divided into three groups (control, BRE, and WRE). Plasma HDL-cholesterol was significantly higher, and thiobarbituric, acid-reactive substances were significantly lower in the BRE group, whereas plasma levels of total cholesterol and triglyceride were not affected by BRE supplementation. Increased hepatic SOD and CAT activities were observed in BRE-treated mice as compared to the control mice. However, no changes were detected for the protein expression of antioxidant enzymes by Western blot analysis. Our data suggest that antioxidative effects exerted by BRE are mediated through decreases in free-radical generation as well as increases in SOD and CAT activities both in vitro and in vivo.read more
Citations
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Journal ArticleDOI
New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?
TL;DR: Benefits of nutrigenomics to study complex physiological effects of the ‘whole-grain package’, and the most promising ways for improving the nutritional quality of cereal products are discussed.
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Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo?
TL;DR: The in vitro antioxidant capacity of cereals is only an approximate reflection of their in vivo antioxidant effect due to differences in antioxidant solubility/bioavailability within the digestive tract and the metabolism/conjugation of compounds such as polyphenols as mentioned in this paper.
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Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity
Fabio Virgili,Maria Marino +1 more
TL;DR: The current knowledge of the mechanisms by which specific molecules of nutritional interest, and in particular polyphenols, play a role in cellular response and in preventing pathologies are summarized.
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Phenolic Compounds and Bioactivities of Pigmented Rice
TL;DR: This review provides up-to-date coverage of pigmented rice in regard to bioactive constituents, extraction and analytical methods, and bioactivities including antioxidant and free radical scavenging, antitumor, antiatherosclerosis, hypoglycemic, and antiallergic activities.
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Proanthocyanidins, anthocyanins and cardiovascular diseases
TL;DR: In this paper, the authors review basic science and clinical evidence for the effectiveness of these flavonoids against cardiovascular disease and discuss the possible mechanisms of action and cellular signalling pathways involved in this effect.
References
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