Journal ArticleDOI
Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity
Fabio Virgili,Maria Marino +1 more
TLDR
The current knowledge of the mechanisms by which specific molecules of nutritional interest, and in particular polyphenols, play a role in cellular response and in preventing pathologies are summarized.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2008-11-01. It has received 228 citations till now.read more
Citations
More filters
Journal ArticleDOI
Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
TL;DR: Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Journal ArticleDOI
Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action
David Vauzour,Ana Rodriguez-Mateos,Giulia Corona,Maria Jose Oruna-Concha,Jeremy P. E. Spencer +4 more
TL;DR: The role that polyphenols play in the prevention of cancer, cardiovascular disease and neurodegeneration is provided and epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions are presented.
Journal ArticleDOI
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Mark A. Feitelson,Alla Arzumanyan,Rob J. Kulathinal,Stacy W. Blain,Randall F. Holcombe,Jamal Mahajna,Maria Marino,María L. Martínez-Chantar,Roman Nawroth,Isidro Sánchez-García,Dipali Sharma,Neeraj K. Saxena,Neetu Singh,Panagiotis J. Vlachostergios,Shanchun Guo,Kanya Honoki,Hiromasa Fujii,Alexandros G. Georgakilas,Alan Bilsland,Amedeo Amedei,Elena Niccolai,Amr Amin,S. Salman Ashraf,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Katia Aquilano,Sophie Chen,Sulma I. Mohammed,Asfar S. Azmi,Dipita Bhakta,Dorota Halicka,W. Nicol Keith,Somaira Nowsheen +33 more
TL;DR: Natural compounds found to inhibit one or more pathways that contribute to proliferation have been found and will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.
Journal ArticleDOI
Dietary factors affecting polyphenol bioavailability
TL;DR: Increased knowledge of the factors affecting polyphenol bioavailability, including dietary factors, is paramount and polyphenols may act synergistically due to their influence on efflux transporters such as p-glycoprotein.
Journal ArticleDOI
Phytochemicals of Brassicaceae in plant protection and human health - Influences of climate, environment and agronomic practice
Maria Björkman,Ingeborg Klingen,A. N. E. Birch,Atle M. Bones,Toby J. A. Bruce,Tor J. Johansen,Richard Meadow,Jørgen A.B. Mølmann,Randi Seljåsen,Lesley E. Smart,Derek Stewart +10 more
TL;DR: The role of glucosinolates and other phytochemical compounds present in the Brassicaceae in relation to plant protection and human health is provided and multi-factorial approaches are briefly discussed.
References
More filters
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Polyphenols: food sources and bioavailability
TL;DR: The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.