Antiretroviral Treatment for Children with Peripartum Nevirapine Exposure
Paul Palumbo,Jane C. Lindsey,Michael Hughes,Mark F. Cotton,Raziya Bobat,Tammy Meyers,Mutsawashe Bwakura-Dangarembizi,Benjamin H. Chi,Philippa Musoke,Portia Kamthunzi,Werner Schimana,Lynette Purdue,Susan H. Eshleman,Susan H. Eshleman,Elaine J. Abrams,Linda Millar,Elizabeth Petzold,Lynne M. Mofenson,Patrick Jean-Philippe,Avy Violari +19 more
TLDR
Among children with prior exposure to single-dose nevirapine for perinatal prevention of HIV transmission, antiretroviral treatment consisting of zidovudine and lamivudine plus ritonavir-boosted lopinavir resulted in better outcomes than did treatment with zidvudineand lamivUDine plus ne virapine.Abstract:
Background Single-dose nevirapine is the cornerstone of the regimen for prevention of mother-to-child transmission of human immunodeficiency virus (HIV) in resource-limited settings, but nevirapine frequently selects for resistant virus in mothers and children who become infected despite prophylaxis. The optimal antiretroviral treatment strategy for children who have had prior exposure to single-dose nevirapine is unknown. Methods We conducted a randomized trial of initial therapy with zidovudine and lamivudine plus either nevirapine or ritonavir-boosted lopinavir in HIV-infected children 6 to 36 months of age, in six African countries, who qualified for treatment according to World Health Organization (WHO) criteria. Results are reported for the cohort that included children exposed to single-dose nevirapine prophylaxis. The primary end point was virologic failure or discontinuation of treatment by study week 24. Enrollment in this cohort was terminated early on the recommendation of the data and safety ...read more
Citations
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Journal ArticleDOI
Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection
Peter Brocklehurst,J Volmink +1 more
TL;DR: To assess which antiretroviral therapies may be effective in decreasing the risk of mother-to-child transmission of HIV infection as well as their effect on neonatal and maternal mortality and morbidity, the Cochrane Controlled Trials Register and conference abstracts were searched.
Journal ArticleDOI
Response to Antiretroviral Therapy After a Single, Peripartum Dose of Nevirapine
Shahin Lockman,Roger L. Shapiro,Laura M. Smeaton,Carolyn Wester,Ibou Thior,Lisa Stevens,Fatima Chand,Joseph Makhema,Claire Moffat,Aida Asmelash,Patrick Ndase,Peter Arimim Eri Van Widenfelt,Loeto Mazhani,Vladimir Novitsky,Stephen W. Lagakos,Max Essex +15 more
TL;DR: Women who received a single dose of nevirapine to prevent perinatal transmission of HIV-1 had higher rates of virologic failure with subsequent ne virapine-based antiretroviral therapy than did women without previous exposure to nevirAPine.
Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children: Recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics
Lynne M. Mofenson,Michael T. Brady,Susie P Danner,Kenneth L. Dominguez,Rohan Hazra,Edward Handelsman,Peter L. Havens,Steve Nesheim,Jennifer S. Read,Leslie Serchuck,Russell B. Van Dyke +10 more
TL;DR: This report updates and combines into one document earlier versions of guidelines for preventing and treating opportunistic infections (OIs) among HIV-exposed and HIV-infected children, last published in 2002 and 2004.
Journal ArticleDOI
Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children.
Avy Violari,Jane C. Lindsey,Michael Hughes,Hilda Mujuru,Linda Barlow-Mosha,Portia Kamthunzi,Benjamin H. Chi,Mark F. Cotton,Harry Moultrie,Sandhya Khadse,Werner Schimana,Raziya Bobat,Lynette Purdue,Susan H. Eshleman,Elaine J. Abrams,Linda Millar,Elizabeth Petzold,Lynne M. Mofenson,Patrick Jean-Philippe,Paul Palumbo +19 more
TL;DR: Outcomes were superior with ritonavir-boosted lopinavir among young children with no prior exposure to nevirapine in a randomized trial conducted in six African countries and India.
Journal ArticleDOI
First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial.
Linda Harrison,Abdel Babiker,Hannah Castro,Alexandra Compagnucci,Susan A. Fiscus,Carlo Giaquinto,Diana M. Gibb,Lynda Harper,Michael Hughes,Ross E. McKinney,Ann J. Melvin,Lynne M. Mofenson,Yacine Saidi,M. Elizabeth Smith,Gareth Tudor-Williams,A. Sarah Walker,Pim Brouwers,D. Costello,E. Ferguson,Janice Hodge,C. Jennings,Meredith G. Warshaw,Stephen A. Spector,E. R. Stiehm,Maripat Toye,Ram Yogev,J. P. Aboulker,A. De Rossi,J. Darbyshire,M. Debré,Nigel Klein,Deenan Pillay,B. Brody,C. Hill,P. Lepage,John F. Modlin,A. Poziak,M. Rein,Merlin L. Robb,T. Fleming,Stefano Vella,K. M. Kim,Rosa Bologna,D. Mecikovsky,N. Pineda,L. Sen,A. Mangano,S. Marino,C. Galvez,G. Deluchi,B. Zöhrer,W. Zenz,E. Daghofer,K. Pfurtscheller,B. Pabst,M. P. Gomez,P. McNeil,M. Jervis,I. Whyms,D. Kwolfe,S. Scott,M. M. Mussi-Pinhata,M. L. Issac,M. C. Cervi,B. V.M. Negrini,T. C. Matsubara,C. B. S. de Souza,J. C. Gabaldi,Ricardo H. Oliveira,M. C. Sapia,Thalita F. Abreu,Lucia de Araujo Evangelista,A. Pala,Iraina Fernandes,I. Farias,M. F. Melo,H. Carreira,L. M. Lira,M. della Negra,W. Queiroz,Y. C. Lian,D. P. Pacola,Jorge Pinto,F. Ferreira,F. Kakehasi,L. Martins,A. Diniz,V. Lobato,M. Diniz,S. Cleto,S. Costa,J. Romeiro,Catherine Dollfus,Marco Tabone,M. F. Courcoux,G. Vaudre,A. Dehée,A. Schnuriger,N. Le Gueyades,C. De Bortoli,F. Méchinaud,V. Reliquet,J. Arias,A. Rodallec,E. André,I. Falconi,A. Le Pelletier,F. Monpoux,J. Cottalorda,S. Mellul,E. Lachassinne,J. Galimand,Christine Rouzioux,Marie-Laure Chaix,Z. Benabadji,M. Pourrat,G. Firtion,D. Rivaux,M. Denon,N. Boudjoudi,F. Nganzali,A. Krivine,J. F. Méritet,G. Delommois,C. Norgeux,C. Guérin,C. Floch,L. Marty,H. Hichou,V. Tournier,Albert Faye,I. Le Moal,M. Sellier,L. Dehache,F. Damond,J. Leleu,D. Beniken,G. Alexandre-Castor,J. Neubert,T. Niehues,H. J. Laws,K. Huck,S. Gudowius,H. Loeffler,S. Bellert,A. Ortwin,G. Notheis,U. Wintergerst,F. Hoffman,A. Werthmann,S. Seyboldt,Laura Schneider,B. Bucholz,Cornelia Feiterna-Sperling,C. Peiser,R. Nickel,T. Schmitz,T. Piening,C. Müller,Gert Warncke,M. Wigger,R. Neubauer,Karina Butler,A. L. Chang,T. Belger,A. Menon,M. O’connell,L. Barrett,A. Rochford,M. Goode,E. Hayes,S. McDonagy,A. Walsh,A. Doyle,J. Fanning,M. O’connor,M. Byrne,N. O’sullivan,E. Hyland,Vania Giacomet,Alessandra Viganò,I. Colombo,Daria Trabattoni,Angela Berzi,Raffaele Badolato,F. Schumacher,V. Bennato,M. Brusati,A. Sorlini,Elena Spinelli,M. Filisetti,Cristina Bertulli,Osvalda Rampon,Marisa Zanchetta,Antonio Mazza,G. Stringari,G. Rossetti,Stefania Bernardi,Angela Di Martino,G. Castelli Gattinara,Paolo Palma,G. Pontrelli,H. Tchidjou,A. Furcas,C. Frillici,A. Mazzei,A. Zoccano,C. Concato,D. Duiculescu,Cristiana Oprea,G. Tardei,F. Abaab,M. Mardarescu,R. Draghicenoiu,D. Otelea,L. Alecsandru,R. Matusa,S. Rugina,M. Ilie,Silvia Netescu,C. Florea,E. Voicu,D. Poalelungi,C. Belmega,L. Vladau,J.T. Ramos Amador,M. I. Gonzalez Tomé,P. Rojo Conejo,M. Fernandez,R. Delgado Garcia,J. M. Ferrari,M. García López,M.J. Mellado Peña,P. Martín Fontelos,I. Jimenez Nacher,M. A. Muñoz Fernandez,J. L. Jimenez,A. García Torre,M. Penin,R. Pineiro Perez,I. Garcia Mellado,A. Finn,M. Lajeunesse,E. Hutchison,J. Usher,L. Ball,M. Dunn,Mike Sharland,K. Doerholt,S. Storey,S. Donaghy,C. Wells,K. Buckberry,P. Rice,P. McMaster,P. Butler,C. Farmer,J. Shenton,H. Haley,J. Orendi,J. Stroobant,L. Navarante,P. Archer,C. Mazhude,D. Scott,R. O’connell,J. Wong,G. Boddy,F. Shackley,R. Lakshman,J. Hobbs,G. Ball,G. Kudesia,J. Bane,D. Painter,K. Sloper,V. Shah,A. Cheng,A. Aali,C. Ball,S. Hawkins,D. Nayagam,A. Waters,S. Doshi,S. Liebeschuetz,B. Sodiende,Delane Shingadia,Delane Shingadia,S. Wong,J. Swan,Z. Shah,Andrew Collinson,C. Hayes,J. King,K. O’connor,Hermione Lyall,K. Fidler,S. Walters,Caroline Foster,D. Hamadache,C. Newbould,C. Monrose,S. Campbell,Shunmay Yeung,Jonathan Cohen,N. Martinez-Allier,D. Melvin,J. Dodge,S. Welch,G. Tatum,Anthony C. Gordon,S. Kaye,D. Muir,D. Patel,V. Novelli,D. Gibb,K. Moshal,John S. Lambert,J. Flynn,L. Farrelly,L. Farrelly,M. Clapson,L. S. Spencer,M. Depala,Marianne C. Jacobsen,S. Segal,Andrew J. Pollard,S. Yeadon,Y. Peng,Tao Dong,K. Jeffries,M. Snelling,A. Smyth,J. Smith,B. Ward,E Jungmann,C. Ryan,K. Swaby,A. Buckton,E. Smidt,Elaine J. Abrams,S. Champion,A. D. Fernandez,D. Calo,L. Garrovillo,K. Swaminathan,T. Alford,M. Frere,J. Navarra,William Borkowsky,S. Deygoo,T. Hastings,S. Akleh,T. Ilmet,K. Mohan,G. Bowen,Patricia Emmanuel,J. Lujan-Zimmerman,C. Rodriguez,S. Johnson,A. Marion,C. Graisbery,D. Casey,G. Lewis,Judith A. Guzman-Cottrill,R. Croteau,M. Acevedo-Flores,M. Gonzalez,L. Angeli,L. Fabregas,P. Valentin,Leonard B. Weiner,K. A. Contello,W. A. Holz,M. Butler,Sharon Nachman,M. A. Kelly,D. M. Ferraro,Sohail Rana,C. Reed,E. Yeagley,A. Malheiro,J. C. Roa,M. Neely,Andrea Kovacs,James Homans,Y. Rodriguez Lozano,Ana Puga,G. Talero,R. Sellers,R. Lawrence,Geoffrey A. Weinberg,Barbra Murante,Susan Laverty,A. Deveikis,J. Batra,T. Chen,D. Michalik,Jaime G. Deville,K. Elkins,S. Marks,J. Jackson Alvarez,J. Palm,I. Fineanganofo,M. Keuth,L. Deveikis,W. Tomosada,R. B. Van Dyke,T. Alchediak,Margarita Silio,C. Borne,S. Bradford,S. Eloby-Childress,K. Nguyen,Mobeen H. Rathore,A. Alvarez,Ayesha Mirza,Saniyyah Mahmoudi,M. Burke,I. L. Febo,L. Lugo,R. Santos,Joseph A. Church,T. Dunaway,C. Rodier,Patricia M. Flynn,N. Patel,S. Discenza,M. Donohoe,Katherine Luzuriaga,D. Picard,M. Kline,M. E. Paul,William T. Shearer,C. McMullen-Jackson,Ellen G. Chadwick,E. Cagwin,K. Kabat,Arry Dieudonne,Paul Palumbo,J. Johnson,S. Gaur,L. Cerracchio,Marc Foca,A. Jurgrau,S. Vasquez Bonilla,G. Silva,Anne A. Gershon,John L. Sullivan,Yvonne J. Bryson,Lisa M. Frenkel,J. Nelson,G. Hadjou,S. Léonardo,Yoann Riault,Y. Saïdi,L. Buck,J. H. Darbyshire,S. Forcat,J. Horton,D. Johnson,S. Moore,C. Taylor,D. Collins,S. Buskirk,P. Kamara,C. Nesel,M. Johnson,A. Ferreira,J. Tutko,H. Sprenger,Paula Britto,Christine A. Powell,R. Dersimonian,Edward Handelsman,Jintanat Ananworanich,E. Belfrage,S. Blanche,A. B. Bohlin,David M. Burger,Guido Castelli-Gattinara,Polly Clayden,R. de Groot,I. Grosch-Wörner,Marc Lallemant,Jay A. Levy,Magdalena Marczyńska,David Nadal,CS Peckham,L. Rosado,Raffaella Rosso,Christoph Rudin,Henriette J. Scherpbier,M. Stevanovic,Claire Thorne,Pier-Angelo Tovo,Niels Henrik Valerius +496 more
TL;DR: The long-term outcome of protease inhibitor and non-nucleoside reverse transcriptase inhibitor (NNRTI) first-line ART and viral load switch criteria in children with HIV is assessed.
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Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).
Susan H. Eshleman,Martin Mracna,Laura Guay,Martina Deseyve,Shawn Cunningham,Mark Mirochnick,Philippa Musoke,Thomas Fleming,Mary Glenn Fowler,Lynne M. Mofenson,Francis Mmiro,J. Brooks Jackson +11 more
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Gonzague Jourdain,Nicole Ngo-Giang-Huong,Sophie Le Coeur,Chureeratana Bowonwatanuwong,Pacharee Kantipong,Pranee Leechanachai,Surabhon Ariyadej,Prattana Leenasirimakul,Scott M. Hammer,Marc Lallemant +9 more
TL;DR: Women who received intrapartum nevirapine were less likely to have virologic suppression after six months of postpartum treatment with a ne virapine-containing regimen, and the need for strategies to maximize the benefits of both antiretroviral prophylaxis against mother-to-child transmission of HIV and antireTroviral therapy for mothers is suggested.
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Journal ArticleDOI
Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine
Shahin Lockman,Roger L. Shapiro,Laura M. Smeaton,Carolyn Wester,Ibou Thior,Lisa Stevens,Fatima Chand,Joseph Makhema,Claire Moffat,Aida Asmelash,Patrick Ndase,Peter Arimi,Erik van Widenfelt,Loeto Mazhani,Vladimir Novitsky,Stephen W. Lagakos,Max Essex +16 more
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Journal ArticleDOI
Response to Antiretroviral Therapy After a Single, Peripartum Dose of Nevirapine
Shahin Lockman,Roger L. Shapiro,Laura M. Smeaton,Carolyn Wester,Ibou Thior,Lisa Stevens,Fatima Chand,Joseph Makhema,Claire Moffat,Aida Asmelash,Patrick Ndase,Peter Arimim Eri Van Widenfelt,Loeto Mazhani,Vladimir Novitsky,Stephen W. Lagakos,Max Essex +15 more
TL;DR: Women who received a single dose of nevirapine to prevent perinatal transmission of HIV-1 had higher rates of virologic failure with subsequent ne virapine-based antiretroviral therapy than did women without previous exposure to nevirAPine.