Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin
Karen E. Brown,Simon Guest,Stephen T. Smale,Kyungmin Hahm,Matthias Merkenschlager,Amanda G. Fisher +5 more
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TLDR
It is shown that transcriptionally inactive but not transcriptionally active genes associate with Ikaros-heterochromatin foci, which support a model of organization of the nucleus in which repressed genes are selectively recruited into centromeric domains.About:
This article is published in Cell.The article was published on 1997-12-12 and is currently open access. It has received 789 citations till now. The article focuses on the topics: Ikaros Transcription Factor & Heterochromatin.read more
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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Chromosome territories, nuclear architecture and gene regulation in mammalian cells.
TL;DR: The emerging view is that chromosomes are compartmentalized into discrete territories and the location of a gene within a chromosome territory seems to influence its access to the machinery responsible for specific nuclear functions, such as transcription and splicing.
Nuclear architecture and gene regulation in mammalian cells
TL;DR: The emerging view is that chromosomes are compartmentalized into discrete territories, and the location of a gene within a chromosome territory seems to influence its access to the machinery responsible for specific nuclear functions, such as transcription and splicing.
Journal ArticleDOI
Chromatin architecture reorganization during stem cell differentiation
Jesse R. Dixon,Inkyung Jung,Siddarth Selvaraj,Yin Shen,Jessica Antosiewicz-Bourget,Ah Young Lee,Zhen Ye,Audrey Kim,Nisha Rajagopal,Wei Xie,Yarui Diao,Jing Liang,Huimin Zhao,Victor V. Lobanenkov,Joseph R. Ecker,James A. Thomson,Bing Ren +16 more
TL;DR: Mapping genome-wide chromatin interactions in human embryonic stem cells and four human ES-cell-derived lineages reveals extensive chromatin reorganization during lineage specification, providing a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages.
References
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Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.
TL;DR: Cyclin and the auxiliary protein of DNA polymerase-δ are identical, and it is reported here that these two are identical.
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Purification and biochemical characterization of the promoter-specific transcription factor, Sp1
TL;DR: Isolation and renaturation of proteins purified from sodium dodecyl sulfate polyacrylamide gels allowed the identification of two polypeptides as those responsible for recognizing and interacting specifically with the GC-box promoter elements characteristic of Sp1 binding sites.
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The Ikaros gene is required for the development of all lymphoid lineages.
Katia Georgopoulos,Michael Bigby,Jin-Hong Wang,Arpad Molnar,Paul W. Wu,Susan Winandy,Arlene H. Sharpe +6 more
TL;DR: It is proposed that Ikaros promotes differentiation of pluripotential hematopoietic stem cell(s) into the lymphocyte pathways through the erythroid and myeloid lineages in mutant mice.
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Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
Karsten Weis,Sophie Rambaud,Catherine Lavau,Joop H. Jansen,Teresa Carvalho,Maria Carmo-Fonseca,Angus I. Lamond,Anne Dejean +7 more
TL;DR: It is shown that PML is specifically localized within a discrete subnuclear compartment corresponding to nuclear bodies recognized by patient autoimmune sera and proposed that the beneficial role of RA in promoting myeloid differentiation in APL might be related to its ability to restore a normal subnuclear organization.
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Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation
Jin-Hong Wang,Aliki Nichogiannopoulou,Li Wu,Lei Sun,Arlene H. Sharpe,Michael Bigby,Katia Georgopoulos +6 more
TL;DR: The lymphoid defects detected in Ikaros null mice reveal critical molecular differences between fetal and postnatal hematopoietic progenitors that dictate their ability to give rise to T cells and establish IkarOS as a tumor suppressor gene acting during thymocyte differentiation.