Journal ArticleDOI
B cell immunopathology during HIV-1 infection: Lessons to learn for HIV-1 vaccine design
Reads0
Chats0
TLDR
Novel data indicate that B cell activation may be at the basis of impaired immune responses and the molecular events leading to B cell damage must be further characterized with the aim of selecting vaccine components allowing preservation of B cell functions.About:
This article is published in Vaccine.The article was published on 2008-06-06. It has received 56 citations till now. The article focuses on the topics: B cell & Vaccination.read more
Citations
More filters
Journal ArticleDOI
B cells in HIV infection and disease
Susan Moir,Anthony S. Fauci +1 more
TL;DR: This Review focuses on advances in understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B- cell dysfunction.
Journal ArticleDOI
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
Susan Moir,Clarisa M. Buckner,Jason Ho,Wei Wang,J. Chen,J. Chen,Amy J. Waldner,Jacqueline G. Posada,Lela Kardava,Marie A. O'Shea,Shyam Kottilil,Tae-Wook Chun,Michael A. Proschan,Anthony S. Fauci +13 more
TL;DR: Investigation of B cells before and after reduction of HIV plasma viremia by antiretroviral therapy provides new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage.
Journal ArticleDOI
Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children
Simone Pensieroso,Alberto Cagigi,Paolo Palma,Anna Nilsson,Claudia Capponi,Elio Freda,Stefania Bernardi,Rigmor Thorstensson,Francesca Chiodi,Paolo Rossi +9 more
TL;DR: Timing of HAART initiation is the major factor predicting the longevity of B cell responses in vaccinated HIV-1-infected children, and both late-treated HIV- 1 controllers and noncontrollers loose protective antibody titers against common vaccination antigens.
Journal ArticleDOI
Marginal Zone B-Cells, a Gatekeeper of Innate Immunity
Moncef Zouali,Yolande Richard +1 more
TL;DR: The multiple roles of MZ B-cells in humans, non-human primates, and rodents are discussed and it is revealed that viruses and bacteria have developed strategies to deplete innate-like B- cells during the acute phase of infection and to impair the antibody response.
Journal ArticleDOI
The TLR9 Ligand CpG Promotes the Acquisition of Plasmodium falciparum-Specific Memory B Cells in Malaria-Naive Individuals
Peter D. Crompton,Marko Mircetic,Greta E Weiss,Amy W. Baughman,Chiung Yu Huang,David J. Topham,John J. Treanor,Iñaki Sanz,F. Eun-Hyung Lee,Anna P. Durbin,Kazutoyo Miura,David L. Narum,Ruth D. Ellis,Elissa Malkin,Gregory E. D. Mullen,Louis H. Miller,Laura B. Martin,Susan K. Pierce +17 more
TL;DR: It is shown that the acquisition of MBC is a dynamic process in which the vaccine-specific MBC pool rapidly expands and then contracts, and that CpG enhances the kinetics, magnitude, and longevity of this response.
References
More filters
Journal ArticleDOI
Detection of peripheral HIV-1-specific memory B cells in patients untreated or receiving highly active antiretroviral therapy.
Jean-Michel Fondere,Marie-France Huguet,Hans Yssel,Vincent Baillat,Jacques Reynes,Philippe Van de Perre,Jean-Pierre Vendrell +6 more
TL;DR: Circulating memory HIV-1-specific B cells were detected in untreated patients and in about half of the patients taking HAART, suggesting that persistent low-level ongoing viral replication is not sufficient to maintain HIV- 1-specific memory B cells.
Journal ArticleDOI
The dynamics of the B follicle: understanding the normal counterpart of B-cell-derived malignancies.
TL;DR: This article aims to form an excellent base for a better understanding of the normal counterpart of B-cell-derived haematological malignancies (leukemias and lymphomas) through a review of up-to-date information on peripheral B- cell differentiation into a challenging working model.
Journal ArticleDOI
Early depletion of proliferating B cells of germinal center in rapidly progressive simian immunodeficiency virus infection
Zhiqiang Zhang,Danilo R. Casimiro,William A. Schleif,Minchun Chen,Michael P. Citron,Mary-Ellen Davies,Janine A. Burns,Xiaoping Liang,Tong-Ming Fu,Larry Handt,Emilio A. Emini,John W. Shiver +11 more
TL;DR: Early severe depletion of GC proliferating B cells and disruption of the FDC network may result in an inability to mount a virus-specific antibody response in rapid progressors, which has been shown to contribute to accelerated disease progression of SIV infection.
Journal ArticleDOI
Increased frequency of CD27- (naive) B cells and their phenotypic alteration in HIV type 1-infected patients.
Yong Chong,Hideyuki Ikematsu,Masahiro Yamamoto,Masayuki Murata,Kouzaburo Yamaji,Mika Nishimura,Shigeki Nabeshima,Seizaburo Kashiwagi,Jun Hayashi +8 more
TL;DR: The CD27- B cells of drug-naive patients showed an increased susceptibility to apoptosis, characterized by diminished cell size and a high frequency of annexin-V binding, compared with controls and HAART-treated patients, which suggested that HIV-1 infection affects peripheralCD27- (naive) B cells as well as CD27+ (memory) B Cells and that CD27 - B cells might be activated and rendered highly susceptible to apoptotic by HIV- 1 infection.
Journal ArticleDOI
Varicella vaccination in HIV-1-infected children after immune reconstitution.
Vincent Bekker,Geertje H.A. Westerlaken,Henriette J. Scherpbier,Sophie Alders,Hans L. Zaaijer,Debbie van Baarle,Taco W. Kuijpers +6 more
TL;DR: VZV vaccination of previously immunocompromised HIV-1-infected children was safe and induced specific immune responses in some of the vaccinated HIV- 1- Infected children, suggesting that previously immunopromised individuals are protected against severe forms of varicella.