Journal ArticleDOI
B cell immunopathology during HIV-1 infection: Lessons to learn for HIV-1 vaccine design
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TLDR
Novel data indicate that B cell activation may be at the basis of impaired immune responses and the molecular events leading to B cell damage must be further characterized with the aim of selecting vaccine components allowing preservation of B cell functions.About:
This article is published in Vaccine.The article was published on 2008-06-06. It has received 56 citations till now. The article focuses on the topics: B cell & Vaccination.read more
Citations
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B cells in HIV infection and disease
Susan Moir,Anthony S. Fauci +1 more
TL;DR: This Review focuses on advances in understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B- cell dysfunction.
Journal ArticleDOI
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
Susan Moir,Clarisa M. Buckner,Jason Ho,Wei Wang,J. Chen,J. Chen,Amy J. Waldner,Jacqueline G. Posada,Lela Kardava,Marie A. O'Shea,Shyam Kottilil,Tae-Wook Chun,Michael A. Proschan,Anthony S. Fauci +13 more
TL;DR: Investigation of B cells before and after reduction of HIV plasma viremia by antiretroviral therapy provides new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage.
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Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children
Simone Pensieroso,Alberto Cagigi,Paolo Palma,Anna Nilsson,Claudia Capponi,Elio Freda,Stefania Bernardi,Rigmor Thorstensson,Francesca Chiodi,Paolo Rossi +9 more
TL;DR: Timing of HAART initiation is the major factor predicting the longevity of B cell responses in vaccinated HIV-1-infected children, and both late-treated HIV- 1 controllers and noncontrollers loose protective antibody titers against common vaccination antigens.
Journal ArticleDOI
Marginal Zone B-Cells, a Gatekeeper of Innate Immunity
Moncef Zouali,Yolande Richard +1 more
TL;DR: The multiple roles of MZ B-cells in humans, non-human primates, and rodents are discussed and it is revealed that viruses and bacteria have developed strategies to deplete innate-like B- cells during the acute phase of infection and to impair the antibody response.
Journal ArticleDOI
The TLR9 Ligand CpG Promotes the Acquisition of Plasmodium falciparum-Specific Memory B Cells in Malaria-Naive Individuals
Peter D. Crompton,Marko Mircetic,Greta E Weiss,Amy W. Baughman,Chiung Yu Huang,David J. Topham,John J. Treanor,Iñaki Sanz,F. Eun-Hyung Lee,Anna P. Durbin,Kazutoyo Miura,David L. Narum,Ruth D. Ellis,Elissa Malkin,Gregory E. D. Mullen,Louis H. Miller,Laura B. Martin,Susan K. Pierce +17 more
TL;DR: It is shown that the acquisition of MBC is a dynamic process in which the vaccine-specific MBC pool rapidly expands and then contracts, and that CpG enhances the kinetics, magnitude, and longevity of this response.
References
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Journal ArticleDOI
B-cell memory: are subsets necessary?
TL;DR: It is proposed that germinal centres produce memory B cells and plasma cells throughout the immune response and thatMemory B cells arise by the emigration of B cells that are chosen at random from the pool available in the germinals centre.
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CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells.
Jennifer Huggins,Tina Pellegrin,Raymond E. Felgar,Chungwen Wei,Miguel A. Brown,Bo Zheng,Eric C. B. Milner,Steven H. Bernstein,Ignacio Sanz,Martin S. Zand +9 more
TL;DR: The results indicate that under certain conditions, naive B cells increase TLR-9 expression and proliferate to CpG DNA stimulation without BCR signaling, which should be a valuable method to interrogate the antigenic specificity of naïve B cells.
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TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.
Wei Jiang,Michael M. Lederman,Clifford V. Harding,Benigno Rodriguez,Richard J. Mohner,Scott F. Sieg +5 more
TL;DR: It is proposed that the activation and expansion of naïve B cells induced by TLR9 agonists could enhance the potential of these cells to interact with cognate antigens and facilitate cell‐mediated immune responses.
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Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions.
Kehmia Titanji,Francesca Chiodi,Rino Bellocco,Danika Schepis,Lyda M. Osorio,Chiara Tassandin,Giuseppe Tambussi,Sven Grutzmeier,Lucia Lopalco,Angelo De Milito +9 more
TL;DR: B cell dysfunctions found in chronic HIV-1 infection appear during PHI and initiation of antiretroviral therapy early during infection may help to preserve the B cell compartment.
Journal ArticleDOI
Antibody to Capsular Polysaccharides of Streptococcus pneumoniae after Vaccination of Human Immunodeficiency Virus-Infected Subjects with 23-Valent Pneumococcal Vaccine
Maria C. Rodriguez-Barradas,Daniel M. Musher,Christopher J. Lahart,Christine E. Lacke,Jean E. Groover,David A. Watson,Robert E. Baughn,Thomas R. Cate,Gordon Crofoot +8 more
TL;DR: A postvaccination antibody was evaluated to five commonly infecting serotypes of Streptococcus pneumoniae and showed no differences between responses in those with less than 200 and those with 200-500 CD4 cells.