Basal ganglia circuits changes in Parkinson's disease patients.
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TLDR
The findings show how the dopaminergic system exerts influences on widespread brain networks, including motor and cognitive networks, in PD, and is more deviant in more severe disease.About:
This article is published in Neuroscience Letters.The article was published on 2012-08-22 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Subthalamic nucleus & Basal ganglia.read more
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Journal ArticleDOI
Functional connectivity in the basal ganglia network differentiates PD patients from controls.
Konrad Szewczyk-Krolikowski,Menke Ral.,Michal Rolinski,Eugene P. Duff,Gholamreza Salimi-Khorshidi,Nicola Filippini,Giovanna Zamboni,Hu Mtm.,Clare E. Mackay +8 more
TL;DR: It is demonstrated that resting functional connectivity, measured with MRI using an observer-independent method, is reproducibly reduced in the BGN in cognitively intact patients with PD, and increases upon administration of dopaminergic medication.
Journal ArticleDOI
Musically Cued Gait-Training Improves Both Perceptual and Motor Timing in Parkinson’s Disease
Charles-Etienne Benoit,Charles-Etienne Benoit,Simone Dalla Bella,Simone Dalla Bella,Nicolas Farrugia,Nicolas Farrugia,Hellmuth Obrig,Hellmuth Obrig,Stefan Mainka,Sonja A. Kotz,Sonja A. Kotz +10 more
TL;DR: It is demonstrated that auditory cueing leads to benefits beyond gait and support the idea that coupling gait to rhythmic auditory cues in IPD patients relies on a neuronal network engaged in both perceptual and motor timing.
Journal ArticleDOI
A systematic review on the applications of resting-state fMRI in Parkinson's disease: Does dopamine replacement therapy play a role?
Masoud Tahmasian,Masoud Tahmasian,Lisa M. Bettray,Thilo van Eimeren,Alexander Drzezga,Lars Timmermann,Claudia R. Eickhoff,Simon B. Eickhoff,Carsten Eggers +8 more
TL;DR: It is suggested that performing rs-fMRI in de novo patients could be a method of choice to study the fundamental functional abnormalities in PD independent of the effects of DRT, but it is necessary to carefully control for excessive involuntary head motions in the patients not receiving DRT.
Journal ArticleDOI
Neuroimaging of Parkinson's disease: Expanding views.
TL;DR: Overall, neuroimaging has shown that PD is a neurodegenerative disorder involving many neurotransmitters, brain regions, structural and functional connections, and neurocognitive systems, which will be essential for translational efforts to develop better treatments and preventive strategies.
Journal ArticleDOI
Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis
Masoud Tahmasian,Masoud Tahmasian,Masoud Tahmasian,Simon B. Eickhoff,Kathrin Giehl,Frank L. Schwartz,Damian M. Herz,Alexander Drzezga,Thilo van Eimeren,Angela R. Laird,Peter T. Fox,Habibolah Khazaie,Mojtaba Zarei,Carsten Eggers,Claudia R. Eickhoff +14 more
TL;DR: This quantitative neuroimaging meta-analysis aims to identify consistent abnormal intrinsic functional patterns in PD across studies and finds convergent evidence for intrinsic functional disturbances in bilateral inferior parietal lobule (IPL) and the supramarginal gyrus in PD patients compared to healthy subjects.
References
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Investigating Causal Relations by Econometric Models and Cross-Spectral Methods
TL;DR: In this article, the cross spectrum between two variables can be decomposed into two parts, each relating to a single causal arm of a feedback situation, and measures of causal lag and causal strength can then be constructed.
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Parkinsonism: Onset, progression, and mortality
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Functional architecture of basal ganglia circuits: neural substrates of parallel processing
TL;DR: Recent evidence indicating that a parallel functional architecture may also be characteristic of the organization within each individual circuit is discussed, which represents a significant departure from earlier concepts of basal ganglia organization.