Journal ArticleDOI
The biology and function of fibroblasts in cancer
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TLDR
Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components and have a role in creating extracellular matrix structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy.Abstract:
Cancer is associated with fibroblasts at all stages of disease progression. This Review discusses the pleiotropic actions of cancer-associated fibroblasts (CAFs) on tumour cells and postulates that they are likely to be a heterogeneous and plastic population of cells in the tumour microenvironment. Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type that can be live-cultured from post-mortem and decaying tissue. Their resilient adaptation may reside in their intrinsic survival programmes and cellular plasticity. Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable component of the general host response to tissue damage caused by cancer cells. Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components. CAFs have a role in creating extracellular matrix (ECM) structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy. The pleiotropic actions of CAFs on tumour cells are probably reflective of them being a heterogeneous and plastic population with context-dependent influence on cancer.read more
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Journal ArticleDOI
A framework for advancing our understanding of cancer-associated fibroblasts
Erik Sahai,Igor Astsaturov,Edna Cukierman,David G. DeNardo,Mikala Egeblad,Ronald M. Evans,Ronald M. Evans,Douglas T. Fearon,Douglas T. Fearon,Florian R. Greten,Sunil R. Hingorani,Tony Hunter,Richard O. Hynes,Rakesh K. Jain,Tobias Janowitz,Claus Jørgensen,Alec C. Kimmelman,Mikhail G. Kolonin,Robert G. Maki,Robert G. Maki,R. Scott Powers,Ellen Puré,Daniel C. Ramirez,Ruth Scherz-Shouval,Mara H. Sherman,Sheila A. Stewart,Thea D. Tlsty,David A. Tuveson,Fiona M. Watt,Valerie M. Weaver,Ashani T. Weeraratna,Zena Werb +31 more
TL;DR: This Consensus Statement issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance the understanding of this important cell type in the tumour microenvironment.
Journal ArticleDOI
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi,Michael Karin +1 more
TL;DR: How the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity is discussed.
Journal ArticleDOI
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Daniel Öhlund,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Giulia Biffi,Giulia Biffi,Ela Elyada,Ela Elyada,Ana S. Almeida,Ana S. Almeida,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Vincenzo Corbo,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Stephen Hearn,Eun Jung Lee,Eun Jung Lee,Iok In Christine Chio,Iok In Christine Chio,Chang-Il Hwang,Chang-Il Hwang,Hervé Tiriac,Hervé Tiriac,Lindsey A. Baker,Lindsey A. Baker,Dannielle D. Engle,Dannielle D. Engle,Christine Feig,Anne Kultti,Mikala Egeblad,Douglas T. Fearon,James M. Crawford,Hans Clevers,Young-Kyu Park,Young-Kyu Park,David A. Tuveson,David A. Tuveson +40 more
TL;DR: Direct evidence for CAF heterogeneity in PDA tumor biology is provided, providing direct evidence for disease etiology and therapeutic development in mouse and human PDA tissue.
Journal ArticleDOI
Microenvironmental regulation of tumour angiogenesis
TL;DR: The extrinsic regulation of angiogenesis by the tumour microenvironment is discussed, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.
Journal ArticleDOI
Macrophages as regulators of tumour immunity and immunotherapy
David G. DeNardo,Brian Ruffell +1 more
TL;DR: How macrophage shape local immune responses in the tumour microenvironment to both suppress and promote immunity to tumours is described and the potential of targeting tumour-associated macrophages to enhance antitumour immune responses is discussed.
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