Benefits and Harms of Computed Tomography Lung Cancer Screening Strategies: A Comparative Modeling Study for the U.S. Preventive Services Task Force
Harry J. de Koning,Rafael Meza,Sylvia K. Plevritis,Kevin ten Haaf,Vidit Munshi,Jihyoun Jeon,Saadet Ayca Erdogan,Chung Yin Kong,Summer S. Han,Joost van Rosmalen,Sung Eun Choi,Paul F. Pinsky,Amy Berrington de Gonzalez,Christine D. Berg,William C. Black,Martin C. Tammemägi,William D. Hazelton,Eric J. Feuer,Pamela M. McMahon +18 more
TLDR
This study estimates future harms and benefits of lung cancer screening and identifies a set of possible efficient lung cancer Screening policies by using 5 separately developed microsimulation models calibrated to the 2 largest randomized, controlled trials on lung cancer screenings.Abstract:
This comparative modeling study provides estimates of the benefits and harms of computed tomography screening for lung cancer in persons aged 45 through 90 years with various pack-year exposures to...read more
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Journal ArticleDOI
Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement
TL;DR: Although lung cancer screening is not an alternative to smoking cessation, the USPSTF found adequate evidence that annual screening for lung cancer with LDCT in a defined population of high-risk persons can prevent a substantial number of lung cancerrelated deaths.
Journal ArticleDOI
Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial
Harry J. de Koning,Carlijn M. van der Aalst,Pim A. de Jong,Ernst Th. Scholten,Kristiaan Nackaerts,Marjolein A Heuvelmans,Jan-Willem J. Lammers,Carla Weenink,Uraujh Yousaf-Khan,Nanda Horeweg,Susan van 't Westeinde,Mathias Prokop,Willem P.Th.M. Mali,Firdaus A. A. Mohamed Hoesein,Peter M. A. van Ooijen,Joachim G.J.V. Aerts,Michael A. den Bakker,Erik Thunnissen,Johny Verschakelen,Rozemarijn Vliegenthart,Joan Walter,Kevin ten Haaf,Harry J.M. Groen,Matthijs Oudkerk +23 more
TL;DR: In this trial involving high-risk persons, lung-cancer mortality was significantly lower among those who underwent volume CT screening than among thoseWho underwent no screening.
Journal ArticleDOI
The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva
Anton Amann,Anton Amann,Ben de Lacy Costello,Wolfram Miekisch,Jochen K. Schubert,Bogusław Buszewski,Joachim D. Pleil,Norman M. Ratcliffe,Terence H. Risby +8 more
TL;DR: In future studies, combined investigations of a particular compound with regard to human matrices such as breath, urine, saliva and cell culture investigations will lead to novel scientific progress in the field.
Journal ArticleDOI
Cost-Effectiveness of CT Screening in the National Lung Screening Trial
William C. Black,Ilana F. Gareen,Samir Soneji,JoRean D. Sicks,Emmett B. Keeler,Denise R. Aberle,Arash Naeim,Timothy R. Church,Gerard A. Silvestri,Jeremy Gorelick,Constantine Gatsonis +10 more
TL;DR: It is estimated that screening for lung cancer with low-dose CT would cost $81,000 per QALY gained, but it is also determined that modest changes in the authors' assumptions would greatly alter this figure.
Journal ArticleDOI
Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force
Amy B. Knudsen,Ann G. Zauber,Carolyn M. Rutter,Steffie K. Naber,V. Paul Doria-Rose,Chester Pabiniak,Colden Johanson,Sara E. Fischer,Iris Lansdorp-Vogelaar,Karen M. Kuntz +9 more
TL;DR: This microsimulation modeling study of a previously unscreened population undergoing CRC screening that assumed 100% adherence identified a set of model-recommendable strategies that provide similar life-years gained (LYG) and a comparable balance between LYG and screening burden.
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