Journal ArticleDOI
Bioprinting and Cellular Therapies for Type 1 Diabetes
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TLDR
Recent successful attempts to generate β cells are discussed and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes.About:
This article is published in Trends in Biotechnology.The article was published on 2017-11-01. It has received 46 citations till now. The article focuses on the topics: 3D bioprinting & Pancreatic islets.read more
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Journal ArticleDOI
Bioprinting: From Tissue and Organ Development to in Vitro Models.
TL;DR: The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.
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Essential steps in bioprinting: From pre- to post-bioprinting
TL;DR: This review, for the first time, puts all the bioprinting stages in perspective of the whole process of biopprinting, and analyzes their current state of the art.
Journal ArticleDOI
Bioprinting functional tissues
Ashley N. Leberfinger,Shantanab Dinda,Yang Wu,Srinivas V. Koduru,Veli Ozbolat,Dino J. Ravnic,Ibrahim T. Ozbolat +6 more
TL;DR: Several factors that are critical for printing functional tissues including cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function are discussed to inform the reader with future directions in bioprinting complex and volumetric tissues.
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Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes
Gorka Orive,Dwaine F. Emerich,Ali Khademhosseini,Shinichi Matsumoto,R.M. Hernández,J.L. Pedraz,Tejal A. Desai,Riccardo Calafiore,Paul de Vos +8 more
TL;DR: The status of the most advanced and widely explored implementations of cell encapsulation are highlighted with an eye toward translating the potential of this technological approach to medical reality.
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Gene therapy and type 1 diabetes mellitus.
Dinesh Kumar Chellappan,Nandhini S. Sivam,Kai Xiang Teoh,Wai Pan Leong,Tai Zhen Fui,Kien Chooi,Nico Khoo,Fam Jia Yi,Jestin Chellian,Lim Lay Cheng,Rajiv Dahiya,Gaurav Gupta,Gautam Singhvi,Srinivas Nammi,Philip M. Hansbro,Kamal Dua +15 more
TL;DR: The pros and cons of each of the gene-based therapies have been discussed based on the results collected from the literature, and there are certain interventions that require further detailed studies to ensure their effectiveness.
References
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Journal ArticleDOI
Bioprinting scale-up tissue and organ constructs for transplantation.
TL;DR: In this Opinion, possibilities for the bioprinting scale-up of functional tissue and organ constructs for transplantation are highlighted and alternative approaches, their limitations, and promising directions for new research prospects are provided.
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A prevascularized subcutaneous device-less site for islet and cellular transplantation
Andrew R. Pepper,Boris Gala-Lopez,Rena Pawlick,Shaheed Merani,Tatsuya Kin,A. M. James Shapiro +5 more
TL;DR: It is demonstrated that transient priming of a subcutaneous site supports diabetes-reversing islet transplantation in mouse models without the need for a permanent cell-encapsulation device.
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Three-dimensional bioprinting using self-Assembling scalable scaffold-free "tissue strands" as a new bioink
Yin Yu,Kazim K. Moncal,Jianqiang Li,Weijie Peng,Iris V. Rivero,James A. Martin,Ibrahim T. Ozbolat +6 more
TL;DR: Near 8 cm-long tissue strands with rapid fusion and self-assemble capabilities are bioprinted in solid form for the first time without any need for a scaffold or a mold support or a liquid delivery medium, and facilitated native-like scale-up tissues.
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How to make a functional β-cell
TL;DR: What is currently known about how these strategies could be utilized to generate new β-cells are summarized and how further study into the mechanisms governing later stages of differentiation and the acquisition of functional capabilities could inform this effort are highlighted.
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Islet α cells and glucagon--critical regulators of energy homeostasis.
TL;DR: New data that is relevant to understanding α-cell biology and glucagon action in the brain, liver, adipose tissue and heart, with attention to normal physiology, are reviewed, as well as conditions associated with dysregulated glucagonaction.