Journal ArticleDOI
Bioprinting and Cellular Therapies for Type 1 Diabetes
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TLDR
Recent successful attempts to generate β cells are discussed and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes.About:
This article is published in Trends in Biotechnology.The article was published on 2017-11-01. It has received 46 citations till now. The article focuses on the topics: 3D bioprinting & Pancreatic islets.read more
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Bioprinting: From Tissue and Organ Development to in Vitro Models.
TL;DR: The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.
Journal ArticleDOI
Essential steps in bioprinting: From pre- to post-bioprinting
TL;DR: This review, for the first time, puts all the bioprinting stages in perspective of the whole process of biopprinting, and analyzes their current state of the art.
Journal ArticleDOI
Bioprinting functional tissues
Ashley N. Leberfinger,Shantanab Dinda,Yang Wu,Srinivas V. Koduru,Veli Ozbolat,Dino J. Ravnic,Ibrahim T. Ozbolat +6 more
TL;DR: Several factors that are critical for printing functional tissues including cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function are discussed to inform the reader with future directions in bioprinting complex and volumetric tissues.
Journal ArticleDOI
Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes
Gorka Orive,Dwaine F. Emerich,Ali Khademhosseini,Shinichi Matsumoto,R.M. Hernández,J.L. Pedraz,Tejal A. Desai,Riccardo Calafiore,Paul de Vos +8 more
TL;DR: The status of the most advanced and widely explored implementations of cell encapsulation are highlighted with an eye toward translating the potential of this technological approach to medical reality.
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Gene therapy and type 1 diabetes mellitus.
Dinesh Kumar Chellappan,Nandhini S. Sivam,Kai Xiang Teoh,Wai Pan Leong,Tai Zhen Fui,Kien Chooi,Nico Khoo,Fam Jia Yi,Jestin Chellian,Lim Lay Cheng,Rajiv Dahiya,Gaurav Gupta,Gautam Singhvi,Srinivas Nammi,Philip M. Hansbro,Kamal Dua +15 more
TL;DR: The pros and cons of each of the gene-based therapies have been discussed based on the results collected from the literature, and there are certain interventions that require further detailed studies to ensure their effectiveness.
References
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A microfabricated electrochemical oxygen generator for high-density cell culture arrays
TL;DR: In this paper, a silicon micro-fabricated electrolytic oxygen generator for use in high-density miniature cell culture arrays is presented, which consists of Ti/Pt electrodes patterned at the narrow end of conical hydrophilic silicone microchannels filled with electrolyte.
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A review on design for bioprinting
TL;DR: This review presents design requirements for bioprinting and discusses currently available medical imaging techniques used in acquisition of anatomical models including magnetic resonance imaging and computed tomography, and compares their strengths and limitations.
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Pancreatic islet autoimmunity.
TL;DR: Given the key role of T lymphocytes in T1D, the cartography of autoantigen-derived peptides that are presented to class I-restricted CD8(+) T-cells and class II- restricted CD4(+)T-cells is of outmost importance and is a necessary step in the development of diagnostic T-cell assays and of immunotherapy of T1d.
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CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?
Dario Gerace,Rosetta Martiniello-Wilks,Najah T. Nassif,Sara Lal,Raymond J. Steptoe,Ann M. Simpson +5 more
TL;DR: The novel clustered regularly interspaced short palindromic repeat (CRISPR) gene-editing technology and improved clinical trial design are suggested as strategies to translate pre-clinical success to the clinical setting.
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Endocrine system on chip for a diabetes treatment model
TL;DR: The results suggest that the endocrine system developed in this study is a useful tool for observing dynamical changes in endocrine hormones (GLP-1 and insulin) in a glucose-dependent environment and can potentially be used to screen GLP- 1 analogues and natural insulin and GLp-1 stimulants for diabetes treatment.