Journal ArticleDOI
Bioprinting and Cellular Therapies for Type 1 Diabetes
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TLDR
Recent successful attempts to generate β cells are discussed and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes.About:
This article is published in Trends in Biotechnology.The article was published on 2017-11-01. It has received 46 citations till now. The article focuses on the topics: 3D bioprinting & Pancreatic islets.read more
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Journal ArticleDOI
Engineered microenvironments and microdevices for modeling the pathophysiology of type 1 diabetes
TL;DR: This article will review recent advances in biomimetic modeling of human type 1 diabetes, and suggest ways to synergize systems to model and observe the pathophysiology of autoimmune diabetes with bioengineered therapeutic strategies.
Journal ArticleDOI
3D Bioprinting and Translation of Beta Cell Replacement Therapies for Type 1 Diabetes.
TL;DR: 3D bioprinting is reviewed, which could facilitate translation of BCRTs as well as the current and forthcoming techniques used for biop printing of a BCRT product, to provide meaningful clinical outcomes to all people living with T1D.
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Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice.
Eleonora Di Piazza,Elisabetta Pandolfi,Ilaria Cacciotti,Andrea Del Fattore,Alberto E. Tozzi,Aurelio Secinaro,Luca Borro +6 more
TL;DR: A review of the most recent and remarkable achievements for skin, heart, pancreas, and cartilage bioprinting breakthroughs is provided in this paper, highlighting the critical shortcomings for each tissue type which is keeping this technique from becoming widespread reality.
Journal ArticleDOI
Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus
TL;DR: Technological advances in genome engineering and editing technologies for adequate insulin and insulin analogs production, renewable cellular sources of insulin through transplantation of islets or insulin-producing cells and reprogramming or differentiation of non β cells into β-like cells, used either alone or in combination for diabetes containment are reviewed here along with their future prospects.
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Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes
TL;DR: The role of immune cells and its influence in the development of autoimmunity in Langerhans islets is highlighted and the impact of the immunological factors on future understanding possible recurrence of autoIMmunity on 3D-bioprinted bionic pancreas is discussed.
References
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Journal ArticleDOI
3D bioprinting of tissues and organs
Sean V. Murphy,Anthony Atala +1 more
TL;DR: 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation and developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.
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Generation of functional human pancreatic β cells in vitro
Felicia W. Pagliuca,Jeffrey R. Millman,Mads Gürtler,Michael Saris Segel,Alana Van Dervort,Jennifer Hyoje Ryu,Quinn P. Peterson,Dale L. Greiner,Douglas A. Melton +8 more
TL;DR: A scalable differentiation protocol is reported that can generate hundreds of millions of glucose-responsive β cells from hPSC in vitro that secrete human insulin into the serum of mice shortly after transplantation in a glucose-regulated manner, and transplantation of these cells ameliorates hyperglycemia in diabetic mice.
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3D bioprinting for engineering complex tissues.
TL;DR: Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.
Journal ArticleDOI
Three-dimensional bioprinting of thick vascularized tissues.
TL;DR: A multimaterial 3D bioprinting method is reported that enables the creation of thick human tissues (>1 cm) replete with an engineered extracellular matrix, embedded vasculature, and multiple cell types that can be actively perfused for long durations.
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Type 1 Diabetes Mellitus
Anastasia Katsarou,Soffia Gudbjörnsdottir,Araz Rawshani,Dana Dabelea,Ezio Bonifacio,Barbara J. Anderson,Laura M. Jacobsen,Desmond A. Schatz,Åke Lernmark +8 more
TL;DR: A cure is not available, and patients depend on lifelong insulin injections; novel approaches to insulin treatment, such as insulin pumps, continuous glucose monitoring and hybrid closed-loop systems, are in development.