Journal ArticleDOI
Bioprinting and Cellular Therapies for Type 1 Diabetes
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TLDR
Recent successful attempts to generate β cells are discussed and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes.About:
This article is published in Trends in Biotechnology.The article was published on 2017-11-01. It has received 46 citations till now. The article focuses on the topics: 3D bioprinting & Pancreatic islets.read more
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Journal ArticleDOI
Bioprinting: From Tissue and Organ Development to in Vitro Models.
TL;DR: The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.
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Essential steps in bioprinting: From pre- to post-bioprinting
TL;DR: This review, for the first time, puts all the bioprinting stages in perspective of the whole process of biopprinting, and analyzes their current state of the art.
Journal ArticleDOI
Bioprinting functional tissues
Ashley N. Leberfinger,Shantanab Dinda,Yang Wu,Srinivas V. Koduru,Veli Ozbolat,Dino J. Ravnic,Ibrahim T. Ozbolat +6 more
TL;DR: Several factors that are critical for printing functional tissues including cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function are discussed to inform the reader with future directions in bioprinting complex and volumetric tissues.
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Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes
Gorka Orive,Dwaine F. Emerich,Ali Khademhosseini,Shinichi Matsumoto,R.M. Hernández,J.L. Pedraz,Tejal A. Desai,Riccardo Calafiore,Paul de Vos +8 more
TL;DR: The status of the most advanced and widely explored implementations of cell encapsulation are highlighted with an eye toward translating the potential of this technological approach to medical reality.
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Gene therapy and type 1 diabetes mellitus.
Dinesh Kumar Chellappan,Nandhini S. Sivam,Kai Xiang Teoh,Wai Pan Leong,Tai Zhen Fui,Kien Chooi,Nico Khoo,Fam Jia Yi,Jestin Chellian,Lim Lay Cheng,Rajiv Dahiya,Gaurav Gupta,Gautam Singhvi,Srinivas Nammi,Philip M. Hansbro,Kamal Dua +15 more
TL;DR: The pros and cons of each of the gene-based therapies have been discussed based on the results collected from the literature, and there are certain interventions that require further detailed studies to ensure their effectiveness.
References
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Journal ArticleDOI
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.
TL;DR: Changes occurring in cellular states upon fate modulation are discussed and how the nature of this fluidity is shaping therapeutic approaches to pancreatic disorders such as diabetes and cancer are addressed.
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In vitro evaluation of carbon-nanotube-reinforced bioprintable vascular conduits
TL;DR: It was concluded that CNT-reinforced vascular conduits provided a foundation for mechanically appealing constructs where CNTs could be replaced with natural protein nanofibers for further integration of these conduits in large-scale tissue fabrication.
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Oxygen supply to encapsulated therapeutic cells
TL;DR: The diverse approaches to enhancement of oxygen transport to encapsulated tissue, including manipulation of diffusion distances and oxygen permeability of materials, induction of neovascularization with angiogenic factors and vascularizing membranes, and methods for increasing the oxygen concentration adjacent to encapsulate tissue so as to exceed that in the microvasculature are reviewed.
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Bioengineering of an Intraabdominal Endocrine Pancreas.
David A. Baidal,Camillo Ricordi,Dora M. Berman,Ana Alvarez,Nathalia Padilla,Gaetano Ciancio,E. Linetsky,Antonello Pileggi,Rodolfo Alejandro +8 more
TL;DR: This letter describes islet transplantation onto the omentum with the use of a degradable scaffold in a patient with a 25-year history of type 1 diabetes mellitus who remained insulin-independent for more than 1 year.
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A Microwell Cell Culture Platform for the Aggregation of Pancreatic β-Cells
TL;DR: Using this PEG hydrogel microwell cell-culture method, viable and functional β-cell aggregates of specific sizes were created, providing a platform from which other biologically relevant questions may be answered.