Journal ArticleDOI
Bioprinting and Cellular Therapies for Type 1 Diabetes
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TLDR
Recent successful attempts to generate β cells are discussed and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes.About:
This article is published in Trends in Biotechnology.The article was published on 2017-11-01. It has received 46 citations till now. The article focuses on the topics: 3D bioprinting & Pancreatic islets.read more
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Journal ArticleDOI
Bioprinting: From Tissue and Organ Development to in Vitro Models.
TL;DR: The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.
Journal ArticleDOI
Essential steps in bioprinting: From pre- to post-bioprinting
TL;DR: This review, for the first time, puts all the bioprinting stages in perspective of the whole process of biopprinting, and analyzes their current state of the art.
Journal ArticleDOI
Bioprinting functional tissues
Ashley N. Leberfinger,Shantanab Dinda,Yang Wu,Srinivas V. Koduru,Veli Ozbolat,Dino J. Ravnic,Ibrahim T. Ozbolat +6 more
TL;DR: Several factors that are critical for printing functional tissues including cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function are discussed to inform the reader with future directions in bioprinting complex and volumetric tissues.
Journal ArticleDOI
Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes
Gorka Orive,Dwaine F. Emerich,Ali Khademhosseini,Shinichi Matsumoto,R.M. Hernández,J.L. Pedraz,Tejal A. Desai,Riccardo Calafiore,Paul de Vos +8 more
TL;DR: The status of the most advanced and widely explored implementations of cell encapsulation are highlighted with an eye toward translating the potential of this technological approach to medical reality.
Journal ArticleDOI
Gene therapy and type 1 diabetes mellitus.
Dinesh Kumar Chellappan,Nandhini S. Sivam,Kai Xiang Teoh,Wai Pan Leong,Tai Zhen Fui,Kien Chooi,Nico Khoo,Fam Jia Yi,Jestin Chellian,Lim Lay Cheng,Rajiv Dahiya,Gaurav Gupta,Gautam Singhvi,Srinivas Nammi,Philip M. Hansbro,Kamal Dua +15 more
TL;DR: The pros and cons of each of the gene-based therapies have been discussed based on the results collected from the literature, and there are certain interventions that require further detailed studies to ensure their effectiveness.
References
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Journal ArticleDOI
Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets
Talitha van der Meulen,Alex M. Mawla,Michael R. DiGruccio,Michael W. Adams,Vera Nies,Sophie Dólleman,Siming Liu,Amanda M. Ackermann,Elena L. Caceres,Anna E. Hunter,Klaus H. Kaestner,Cynthia J. Donaldson,Mark O. Huising,Mark O. Huising +13 more
TL;DR: A population of immature beta cells that is present throughout life and forms from non-beta precursors at a specialized micro-environment or "neogenic niche" at the islet periphery is discovered.
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Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics
TL;DR: The currently available tissue models in pharmaceutics along with their limitations are discussed and the possibilities of bioprinting physiologically relevant tissue models, which hold great potential in drug testing, high-throughput screening, and disease modeling are highlighted.
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Evaluation of bioprinter technologies
TL;DR: This paper prefaces the evolution of the field of bioprinting and presents the first comprehensive review of existing bioprinter technologies, where a comparative evaluation is performed for bioprinters.
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Quantitative analysis of cell composition and purity of human pancreatic islet preparations
Anna Pisania,Gordon C. Weir,John J. O'Neil,Abdulkadir Omer,Vaja Tchipashvili,Ji Lei,Clark K. Colton,Susan Bonner-Weir +7 more
TL;DR: Both EM and LM provide accurate methods to determine the cell composition of human islet preparations and can help us understand many of the discrepancies of islet composition in the literature.
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Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation
Giulia Marchioli,L. van Gurp,P P van Krieken,Dimitrios Stamatialis,Marten A. Engelse,C.A. van Blitterswijk,Marcel Karperien,E.J.P. de Koning,Jacqueline Alblas,Lorenzo Moroni,A.A. van Apeldoorn +10 more
TL;DR: 3D bioplotting was used for the fabrication of a 3D alginate-based porous scaffold as an extra-hepatic islet delivery system and INS1E β-cells, human and mouse islets were successfully embedded in 3D-plotted constructs without affecting their morphology and viability, while preventing their aggregation.