Journal ArticleDOI
Bioprinting and Cellular Therapies for Type 1 Diabetes
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TLDR
Recent successful attempts to generate β cells are discussed and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes.About:
This article is published in Trends in Biotechnology.The article was published on 2017-11-01. It has received 46 citations till now. The article focuses on the topics: 3D bioprinting & Pancreatic islets.read more
Citations
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Journal ArticleDOI
Alginate-based tissue-specific bioinks for multi-material 3D-bioprinting of pancreatic islets and blood vessels: A step towards vascularized pancreas grafts
Joanna Idaszek,Marina Volpi,Alessia Paradiso,Martyna Nguyen Quoc,Żaneta Górecka,Marta Klak,Grzegorz Tymicki,Andrzej Berman,Mateusz Wierzbicki,Sławomir Jaworski,Marco Costantini,Marco Costantini,Agnieszka Kępczyńska,Ewa Sawosz Chwalibog,Michal Wszola,Wojciech Święszkowski +15 more
TL;DR: Novel bioinks suitable for the microfluidic-assisted multi-material biofabrication of 3D porous pancreatic and vascular structures are developed and the feasibility of the secondary crosslinking to modulate cell behaviour and angiogenic potential both in vitro and in vivo is demonstrated.
Journal ArticleDOI
Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies.
TL;DR: Basic concepts of pancreatic organogenesis are presented, which intermittently provides a basis for engineering differentiation procedures, mainly based on the use of small molecules, which offer immense benefits in terms of generating efficient functional beta-like cells.
Journal ArticleDOI
Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges.
Ahmed Al-Kattan,David Grojo,Christophe Drouet,Alexandros Mouskeftaras,Philippe Delaporte,Adrien Casanova,Jérôme D. Robin,Frédérique Magdinier,Patricia Alloncle,Catalin Constantinescu,Vincent Motto-Ros,Jörg Hermann +11 more
TL;DR: In this article, the potential of laser-induced breakdown spectroscopy, providing a unique tool for contact-free and space-resolved elemental analysis of organic materials, has been discussed.
Book ChapterDOI
3D Bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks
TL;DR: This chapter explores in depth the parameters that are necessary for a successful bioink solution that can support cardiac tissue structure and function.
Journal ArticleDOI
An insight on advances and applications of 3d bioprinting: A review
Aathma Merin Bejoy,Kausalya Neelavara Makkithaya,Bhagesh Basavraj Hunakunti,Anarghya Hegde,Keerthana Krishnamurthy,Aparajita Sarkar,Carol Felcita Lobo,D.V.S. Keshav,Dharshini G,Dhivya Dharshini S,Selinda Mascarenhas,Shweta Chakrabarti,Sree Raja Rajeswari Devi Kalepu,Bobby Paul,Nirmal Mazumder +14 more
TL;DR: A comprehensive overview of different principles and methods employed for 3D bioprinting can be found in this article, focusing mainly on the applications in tissue engineering and regenerative medicine, 3D organ printing and its transplantation, high-throughput screening, drug and toxicology screening, and clinical research.
References
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Journal ArticleDOI
3D bioprinting of tissues and organs
Sean V. Murphy,Anthony Atala +1 more
TL;DR: 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation and developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.
Journal ArticleDOI
Generation of functional human pancreatic β cells in vitro
Felicia W. Pagliuca,Jeffrey R. Millman,Mads Gürtler,Michael Saris Segel,Alana Van Dervort,Jennifer Hyoje Ryu,Quinn P. Peterson,Dale L. Greiner,Douglas A. Melton +8 more
TL;DR: A scalable differentiation protocol is reported that can generate hundreds of millions of glucose-responsive β cells from hPSC in vitro that secrete human insulin into the serum of mice shortly after transplantation in a glucose-regulated manner, and transplantation of these cells ameliorates hyperglycemia in diabetic mice.
Journal ArticleDOI
3D bioprinting for engineering complex tissues.
TL;DR: Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.
Journal ArticleDOI
Three-dimensional bioprinting of thick vascularized tissues.
TL;DR: A multimaterial 3D bioprinting method is reported that enables the creation of thick human tissues (>1 cm) replete with an engineered extracellular matrix, embedded vasculature, and multiple cell types that can be actively perfused for long durations.
Journal ArticleDOI
Type 1 Diabetes Mellitus
Anastasia Katsarou,Soffia Gudbjörnsdottir,Araz Rawshani,Dana Dabelea,Ezio Bonifacio,Barbara J. Anderson,Laura M. Jacobsen,Desmond A. Schatz,Åke Lernmark +8 more
TL;DR: A cure is not available, and patients depend on lifelong insulin injections; novel approaches to insulin treatment, such as insulin pumps, continuous glucose monitoring and hybrid closed-loop systems, are in development.