Biosensors based on nanomechanical systems
TLDR
This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface: mass, surface stress, effective Young's modulus and viscoelasticity.Abstract:
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface. This review guides the reader through the parameters that change as a consequence of biomolecular adsorption: mass, surface stress, effective Young's modulus and viscoelasticity. The mathematical background needed to correctly interpret the output signals from nanomechanical biosensors is also outlined here. Other practical issues reviewed are the immobilization of biomolecular receptors on the surface of nanomechanical systems and methods to attain that in large arrays of sensors. We then describe some relevant realizations of biosensor devices based on nanomechanical systems that harness some of the mechanical effects cited above. We finally discuss the intrinsic detection limits of the devices and the limitation that arises from non-specific adsorption.read more
Citations
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Biosensors Based on Nanomechanical Systems
TL;DR: In this paper, a review of the properties of biomolecular adsorption on the surface of suspended mechanical structures is presented. But the authors focus on the physical properties of the adsorbed structures and not on the biological interactions that take place on their surface.
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Tunable Micro- and Nanomechanical Resonators
TL;DR: A brief overview of the resonance behavior and frequency tuning principles by varying either the mass or the stiffness of resonators is presented, and the effects of axial stress/strain, residual surface stress and adsorption-induced surface stress on the sensing and detection applications are addressed.
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Transmitter and Receiver Architectures for Molecular Communications: A Survey on Physical Design with Modulation, Coding and Detection Techniques
TL;DR: This comprehensive survey of the existing literature on transmitter and receiver architectures toward realizing molecular communications among nanomaterial-based nanomachines and/or biological entities is reviewed and provides a complete overview of modulation, coding, and detection techniques employed for MC.
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Label-Free Aptasensors for the Detection of Mycotoxins
TL;DR: Current designs in label-free conformational switchable design strategies, with a particular focus on applications in the detection of mycotoxins, are focused on.
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Quantitative detection of potassium ions and adenosine triphosphate via a nanochannel-based electrochemical platform coupled with G-quadruplex aptamers.
TL;DR: A nanochannel-based electrochemical platform developed for the quantitative detection of biorelated small molecules such as potassium ions (K(+)) and adenosine triphosphate (ATP) in a facile way showed significant selectivity, good reproducibility, and universality and showed its potential for use in the detection of other aptamer-based analytes.
References
More filters
Journal ArticleDOI
The Tension of Metallic Films Deposited by Electrolysis
TL;DR: It is well known that metallic films deposited electrolytically are in many cases liable to peel off if deposited to any considerable thickness as discussed by the authors, especially if it does not adhere very tightly to the body on which it is deposited.
Journal ArticleDOI
Carbon‐Nanotube Based Electrochemical Biosensors: A Review
TL;DR: A review of carbon-nanotubes (CNT) based electrochemical biosensors can be found in this paper, where common designs of CNT-based sensors are discussed, along with practical examples of such devices.
Journal ArticleDOI
Frequency modulation detection using high‐Q cantilevers for enhanced force microscope sensitivity
TL;DR: In this article, a frequency modulation (FM) technique has been demonstrated which enhances the sensitivity of attractive mode force microscopy by an order of magnitude or more, which is made possible by operating in a moderate vacuum (<10−3 Torr).
Journal ArticleDOI
Direct observation of the rotation of F1-ATPase
TL;DR: It is shown that a single molecule of F1-ATPase acts as a rotary motor, the smallest known, by direct observation of its motion by attaching a fluorescent actin filament to the γ-subunit as a marker, which enabled us to observe this motion directly.
Journal ArticleDOI
Sensitive optical biosensors for unlabeled targets: a review.
TL;DR: This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms, and focuses on the optical biosENSors that utilize the refractive index change as the sensing transduction signal.