Biosensors based on nanomechanical systems
TLDR
This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface: mass, surface stress, effective Young's modulus and viscoelasticity.Abstract:
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface. This review guides the reader through the parameters that change as a consequence of biomolecular adsorption: mass, surface stress, effective Young's modulus and viscoelasticity. The mathematical background needed to correctly interpret the output signals from nanomechanical biosensors is also outlined here. Other practical issues reviewed are the immobilization of biomolecular receptors on the surface of nanomechanical systems and methods to attain that in large arrays of sensors. We then describe some relevant realizations of biosensor devices based on nanomechanical systems that harness some of the mechanical effects cited above. We finally discuss the intrinsic detection limits of the devices and the limitation that arises from non-specific adsorption.read more
Citations
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Inverse piezoelectricity of single-stranded DNA film on microcantilever
TL;DR: In this article, the authors reveal the relation between the inverse piezoelectricity of singlestranded DNA (ssDNA) film and the origin and sign of the deflection of microcantilever produced by the DNA immobilization using Zhang's two-variable method for strain field of laminated beam and the linearized Poisson-Boltzmann equation for bioelectric potential of polyelectrolyte brush.
Journal ArticleDOI
Achievable accuracy of resonating nanomechanical systems for mass sensing of larger analytes in GDa range
Ivo Stachiv,Zdenek Machu,Oldřich Ševeček,Yeau-Ren Jeng,Wang-Long Li,Michal Kotoul,Jan Prasek +6 more
TL;DR: In this paper , a 3D model capable of accurately predicting the resonant frequencies and vibrational mode shapes of the resonating nanomechanical systems with the bound analyte of arbitrary properties and size is presented.
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Performances and improvement of coupled dual-microcantilevers in sensitivity
TL;DR: In this article, a coupled dual-microcantilever under piezo-actuation was discovered to be easier with smaller damping force, stronger coupling effect and greater mass difference between the two coupled beams.
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Precise measurement of a concentrated mass and its position by the vibration of a rectangular micro-diaphragm
TL;DR: In this article, a Rayleigh-Ritz method was used to construct the mode shape of a diaphragm with a concentrated mass and its position from the observed frequency changes.
Proceedings ArticleDOI
Fabrication and characterisation of ScAlN -based piezoelectric MEMS cantilevers
TL;DR: In this paper, the authors demonstrate the fabrication of MEMS cantilevers actuated by sputter deposited Sc x Al 1−x N thin films sandwiched between gold electrodes.
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