Biosensors based on nanomechanical systems
TLDR
This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface: mass, surface stress, effective Young's modulus and viscoelasticity.Abstract:
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface. This review guides the reader through the parameters that change as a consequence of biomolecular adsorption: mass, surface stress, effective Young's modulus and viscoelasticity. The mathematical background needed to correctly interpret the output signals from nanomechanical biosensors is also outlined here. Other practical issues reviewed are the immobilization of biomolecular receptors on the surface of nanomechanical systems and methods to attain that in large arrays of sensors. We then describe some relevant realizations of biosensor devices based on nanomechanical systems that harness some of the mechanical effects cited above. We finally discuss the intrinsic detection limits of the devices and the limitation that arises from non-specific adsorption.read more
Citations
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Journal ArticleDOI
Two-Photon Polymerization Lithography and Laser Doppler Vibrometry of a SU-8-Based Suspended Microchannel Resonator
Celso Accoto,Antonio Qualtieri,Ferruccio Pisanello,Carlo Ricciardi,Candido Pirri,Massimo De Vittorio,Francesco Rizzi +6 more
TL;DR: In this article, the authors presented the optical realization and characterization of a complex suspended microchannel resonator (SMR) for biomechanical sensing applications, exploiting the flexibility of two-photon direct laser writing to optimize a highly versatile fabrication strategy based on a shell-writing procedure.
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Nanomotion detection based on atomic force microscopy cantilevers.
Anne-Céline Kohler,Leonardo Venturelli,Giovanni Longo,Giovanni Dietler,Sandor Kasas,Sandor Kasas +5 more
TL;DR: The technique is reviewed in details, results obtained with dozens of different microorganisms are presented and the potential applications of nanomotion in fundamental research, medical microbiology and space exploration are discussed.
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Force Sensing with an Optomechanical Self-Oscillator
TL;DR: In this article, a method to optomechanically sense a force field with an ultra-high-frequency and stiff mechanical resonator was proposed, where back-action optical forces set the resonator into a self-sustained stable oscillator trajectory.
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Nanomechanical Sensors as a Tool for Bacteria Detection and Antibiotic Susceptibility Testing
TL;DR: This review aims to provide a perspective on the diverse transducer structures, working principles, and detection strategies of nanomechanical sensors for bacteria detection and antibiotic susceptibility testing and their performance in terms of sensitivity and operation time is compared with standard methods currently used in clinical microbiology laboratories.
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Application of nanotechnology in biosensors for enhancing pathogen detection.
TL;DR: The application of various nanotechnologies for biosensor transduction will be discussed, along with the inherent nanoscale phenomenon that leads to their improved performance and capabilities in biosensor systems.
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