Biosensors based on nanomechanical systems
TLDR
This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface: mass, surface stress, effective Young's modulus and viscoelasticity.Abstract:
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface. This review guides the reader through the parameters that change as a consequence of biomolecular adsorption: mass, surface stress, effective Young's modulus and viscoelasticity. The mathematical background needed to correctly interpret the output signals from nanomechanical biosensors is also outlined here. Other practical issues reviewed are the immobilization of biomolecular receptors on the surface of nanomechanical systems and methods to attain that in large arrays of sensors. We then describe some relevant realizations of biosensor devices based on nanomechanical systems that harness some of the mechanical effects cited above. We finally discuss the intrinsic detection limits of the devices and the limitation that arises from non-specific adsorption.read more
Citations
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Journal ArticleDOI
Note: A resonating reflector-based optical system for motion measurement in micro-cantilever arrays
TL;DR: An optical beam deflection-based system to measure the deflection of micro-cantilevers in an array that employs a single laser source, a single detector, and a resonating reflector to scan the measurement laser across the array.
Journal ArticleDOI
Measurement and reliability issues in resonant mode cantilever for bio-sensing application in fluid medium
TL;DR: In this paper, the authors describe a method to distinguish the normal modes from the spurious modes for a cantilever, based on the actuation signal provided and laser beam size.
Book ChapterDOI
Mechanics for Fluidics and Bio-Devices
TL;DR: This chapter presents mechanical elements which are essential components of Lab-On-Chip devices as they can provide sensing, mixing, pumping and controlled delivery of small fluidic volumes, and discusses the different approaches available to act on cells and perform mechanical phenotyping in microsystems.
Book ChapterDOI
Biochemical Sensors Based on Piezoresistive Microcantilevers
Xiaomei Yu,Rui Zhao +1 more
Abstract: Microcantilevers, which are highly attractive for their small size, high sensitivity, and low cost, have been successfully used in label-free biological and chemical sensing applications during the past 20 years. In this chapter, a piezoresistive microcantilever-based biochemical sensor is introduced, in which a mechanical bending induced by a biochemical reaction or absorption on the surface of the microcantilever is changed into an electrical signal by integrated piezoresistors. Theory and design method are introduced firstly, and then fabrication technique and characteristics of the microcantilever sensors are described in details. Finally, we introduce some biochemical detection results measured with the piezoresistive microcantilever-based sensors.
Journal ArticleDOI
The impact of adsorbate mass on a nanomechanical resonator
Shujun Ma,Xiaoxiao Wang +1 more
TL;DR: In this article, a theoretical analysis on the dynamic characteristics of a nanomechanical resonator attached with an adsorbate at an arbitrary position is presented, and closed-form expressions relating the exact mode shape and the resonant frequency of the loaded resonator are derived using the Rayleigh-Ritz theorem.
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