Biosensors based on nanomechanical systems
TLDR
This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface: mass, surface stress, effective Young's modulus and viscoelasticity.Abstract:
The advances in micro- and nanofabrication technologies enable the preparation of increasingly smaller mechanical transducers capable of detecting the forces, motion, mechanical properties and masses that emerge in biomolecular interactions and fundamental biological processes. Thus, biosensors based on nanomechanical systems have gained considerable relevance in the last decade. This review provides insight into the mechanical phenomena that occur in suspended mechanical structures when either biological adsorption or interactions take place on their surface. This review guides the reader through the parameters that change as a consequence of biomolecular adsorption: mass, surface stress, effective Young's modulus and viscoelasticity. The mathematical background needed to correctly interpret the output signals from nanomechanical biosensors is also outlined here. Other practical issues reviewed are the immobilization of biomolecular receptors on the surface of nanomechanical systems and methods to attain that in large arrays of sensors. We then describe some relevant realizations of biosensor devices based on nanomechanical systems that harness some of the mechanical effects cited above. We finally discuss the intrinsic detection limits of the devices and the limitation that arises from non-specific adsorption.read more
Citations
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Journal ArticleDOI
Resonating Behaviour of Nanomachined Holed Microcantilevers.
Giancarlo Canavese,Alessandro Ricci,Gian Carlo Gazzadi,Ivan Ferrante,Andrea Mura,Simone Luigi Marasso,Carlo Ricciardi +6 more
TL;DR: The nanofabrication of a nanomachined holed structure localized on the free end of a microcantilever is presented, as a new tool to design micro-resonators with enhanced mass sensitivity.
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How to engineer superhydrophobic micromechanical sensors preserving mass resolution
Daniele Borin,Daniele Borin,Mauro Melli,Simone Dal Zilio,Valeria Toffoli,Valeria Toffoli,Giacinto Scoles,Giuseppe Toffoli,Marco Lazzarino +8 more
TL;DR: In this paper, the effect on a micropillar array of different hydrophobic treatments, based on plasma deposition of a fluorocarbon film (FCF) and on the formation of an alkanosilane coating, to obtain a superhydrophobic state.
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Non-stationary response of variable-mass Duffing oscillator with mass disturbance modeled as Gaussian white noise
TL;DR: In this article, the probability density evolution process of a variable-mass Duffing oscillator with mass disturbance modeled as Gaussian white noise was investigated, and the solution procedure based on Gauss-Legendre quadrature integration rule was formulated to obtain and study the probabilistic solutions of the strongly and weekly nonlinear variable mass system.
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Mesoporous Carbon Nanospheres Featured Multifunctional Fluorescent Nanoprobe: Simultaneous Activation and Tracing of Caspase-3 Involved Cell Apoptosis
TL;DR: In this paper , a novel and simple multifunctional peptide-tailored mesoporous carbon nanospheres (MCN) has been developed for simultaneous cancer photothermal therapy (PTT) and real-time imaging of caspase-3 induced cell apoptosis.
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The pH-dependent elastic properties of nanoscale DNA films and the resultant bending signals for microcantilever biosensors.
TL;DR: Several multiscale models are formulating to study the effect of pH-dependent ionic inhomogeneity on the graded elastic properties of nanoscale DNA films and the resultant bending deflections of microcantilever biosensors.
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