Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
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Bisphenol A inhibits voltage-activated Ca 2+ channels in vitro: mechanisms and structural requirements
TL;DR: It is shown that BPA acts as a potent blocker of voltage-activated Ca2+ channels and structure-effect analyses of various phenolic and bisphenolic compounds revealed that the two aromatic moieties in angulated orientation are optimal for BPA’s effectiveness.
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Lifestyle behaviors associated with exposures to endocrine disruptors
TL;DR: The consistent lifestyle of an Old Order Mennonite (OOM) community would provide an ideal setting in which to characterize sources of exposure to BPA and phthalates, and three practices that may contribute to these lower levels are suggested.
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Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats.
TL;DR: The administration of TQ attenuated the BPA-induced oxidative stress, alleviated the antioxidative system and improved to a large extent the liver functioning, indicating that TQ has the potential to be a protective agent against oxidative stress and liver injury.
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Maternal bisphenol a exposure impacts the fetal heart transcriptome.
Kalyan C. Chapalamadugu,Catherine A. VandeVoort,Matthew L. Settles,Barrie D. Robison,Gordon K. Murdoch +4 more
TL;DR: Exposure to BPA during fetal development alters transcription of genes that are recognized for their role in cardiac pathophysiologies, which intensifies concerns about the role of BPA in the genesis of human metabolic and cardiovascular diseases.
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Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice.
Cheryl S. Rosenfeld,Paizlee T. Sieli,Denise A. Warzak,Mark R. Ellersieck,Kathleen A. Pennington,R. Michael Roberts +5 more
TL;DR: Data suggest that Avy/a conceptuses, which may possess a so-called “thrifty genotype,” are at a competitive advantage over a/ a conceptuses in certain uterine environments.
References
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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.