Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
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Evidence for bisphenol A-induced disruption of maternal thyroid homeostasis in the pregnant ewe at low level representative of human exposure.
Davy Guignard,Véronique Gayrard,Marlène Z. Lacroix,Sylvie Puel,Nicole Picard-Hagen,Catherine Viguié +5 more
TL;DR: The goals of this study were to determine the equivalence of subcutaneous and dietary exposures and determine if environmentally relevant doses of BPA can alter gestational and newborn thyroid functions and to suggest an effect at the level of deiodinases.
Journal ArticleDOI
Exploring the molecular aspects associated with testicular germ cell tumors: a review.
Gaetano Facchini,Sabrina Rossetti,Carla Cavaliere,Carmine D'Aniello,Rossella Di Franco,Gelsomina Iovane,Giovanni Grimaldi,Raffaele Piscitelli,Paolo Muto,Gerardo Botti,Sisto Perdonà,Bianca Maria Veneziani,Massimiliano Berretta,Micaela Montanari +13 more
TL;DR: The main genetic and epigenetic events associated with TGCTs development are discussed in order to better define their role in the pathogenesis of these tumors and in cisplatin-acquired resistance.
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Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system.
Isabel Forner-Piquer,Silvia Beato,Fabiana Piscitelli,Stefania Santangeli,Vincenzo Di Marzo,Hamid R. Habibi,Francesca Maradonna,Oliana Carnevali +7 more
TL;DR: Exposure to two environmentally relevant concentrations of BPA altered the ECS and consequently, gonadal function in both male and female zebrafish, and caused changes in the endocannabinoid system.
Journal ArticleDOI
Epigenetic Regulation of Non-Lymphoid Cells by Bisphenol A, a Model Endocrine Disrupter: Potential Implications for Immunoregulation.
Deena Khan,S. Ansar Ahmed +1 more
TL;DR: This review will highlight the BPA regulation of estrogen receptor-mediated immune cell functions and in different inflammatory conditions and BPA-mediated epigenetic regulation of non-lymphoid cells is emphasized.
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Developmental low-dose exposure to bisphenol A induces chronic inflammation, bone marrow fibrosis and reduces bone stiffness in female rat offspring only
Thomas Lind,Margareta Halin Lejonklou,Linda Dunder,Mark M. Kushnir,Mark M. Kushnir,Caroline Öhman-Mägi,Sune Larsson,Håkan Melhus,P. Monica Lind +8 more
TL;DR: Developmental BPA exposure at an environmentally relevant concentration resulted in female-specific effects on bone as well as on plasma biomarkers of collagen synthesis and inflammation, which appeared to induce bone stiffness reduction, bone marrow fibrosis and chronic inflammation in female rat offspring later in life.
References
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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
Journal ArticleDOI
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.