Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
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DissertationDOI
The Effects of Gestational and Lactational Bisphenol A Exposure on Rat Pup Morphometric Measurements and on Adrenal Gland Glucocorticoid Receptor Gene Expression
Journal ArticleDOI
Biotransformation of bisphenol-A bis(diphenyl phosphate): In vitro, in silico, and (non-) target analysis for metabolites in rat and bird liver microsomal models.
TL;DR: In vitro biotransformation of the novel OPE bisphenol-A bis(diphenyl phosphate) (BPADP) using Wistar-Han rat and herring gull liver based microsomal assays suggests that BPADP is biologically persistent in exposed mammals or birds.
Journal Article
BPA exposure is related to metabolic changes in obese Saudi children.
Nasser M. Al-Daghri,Sherif H. Abd-Alrahman,Ihtisham Bukhari,Amaresh Panigrahy,Malak Nk Khattak,Majed S. Alokail +5 more
TL;DR: Higher BPA level in obese children reveals that it may involve in the childhood obesity as it has shown a significant association with the key makers of the obesity in obeseChildren especially in boys.
Journal ArticleDOI
BPA and reproductive health reviewing the current state of the science.
TL;DR: Strong evidence exists that BPA is an ovarian toxicant in both animals and humans and a uterine and prostate Toxicant in animals, and the authors recommend that future studies emphasize critical periods during development and use continuous BPA exposure measures and doses that better reflect actual human exposure.
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Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Journal ArticleDOI
Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
Journal ArticleDOI
Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
Journal ArticleDOI
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Journal ArticleDOI
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.