Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
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Hepatic Detoxification of Bisphenol A is Retinoid-Dependent.
TL;DR: How retinoids, both those stored in the liver and those originating from recent oral intake, help maintain an optimal xenobiotic detoxification response is explored, affecting mRNA expression and activities of elements of xenobiotics detoxification system upon BPA administration to mice.
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Bisphenol A in human saliva and urine before and after treatment with dental polymer-based restorative materials.
Trine Lise Lundekvam Berge,Gunvor Bentung Lygre,Stein Atle Lie,Christian H. Lindh,Lars Björkman +4 more
TL;DR: There was a statistically significant increase of salivary BPA concentration directly after placement of the dental polymer‐based restorations, and following placement, the concentration of BPA decreased exponentially with time.
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A case-control study of Bisphenol A and endometrioma among subgroup of Iranian women
TL;DR: A positive association between urinary BPA concentrations and endometrioma was showed, however, further large-scale studies are needed to confirm this hypothesis.
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A simple method for the enrichment of bisphenols using boron nitride.
TL;DR: A simple solid-phase extraction method for the enrichment of 5 bisphenol derivatives using hexagonal boron nitride (BN) was developed and showed good recovery rates ranging from 80% to 110%.
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Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.
Simon Bucher,Pégah Jalili,Dounia Le Guillou,Karima Begriche,Karine Rondel,Sophie Martinais,Daniel Zalko,Anne Corlu,Marie-Anne Robin,Bernard Fromenty +9 more
TL;DR: HepaRG cells provide a valuable model that can prove useful for the toxicological assessment of endocrine disruptors on hepatic metabolisms, in particular in the developing liver, according to the kinetics of expression of seven proteins differentially expressed during liver development.
References
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Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.