Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
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Micro-QuEChERS extraction coupled to GC-MS for a fast determination of Bisphenol A in human urine.
Luísa Correia-Sá,Sónia Norberto,Cristina Delerue-Matos,Conceição Calhau,Valentina F. Domingues +4 more
TL;DR: A modified Micro-QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method coupled to gas chromatography-mass spectrometry (GC-MS) as a new strategy for the efficient extraction and determination of Bisphenol A in human urine samples is reported.
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Chemical contamination and the thyroid
TL;DR: This review highlights the multifold activity of chemicals demonstrated to cause thyroid disruption and represents a call to action among clinicians to undertake systematic monitoring of thyroid function and registering of the classes of EDs and additionally urges broader scientific collaborations to clarify these chemicals’ molecular mechanisms of action.
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Evaluation of Oxidative stress, antioxidant enzymes and genotoxic potential of bisphenol A in fresh water bighead carp (Aristichthys nobils) fish at low concentrations
TL;DR: The current trial concludes that even at very low concentrations bisphenol A causes toxic effects via turbulences in physiological and biochemical parameters in multiple tissues of fish.
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Review on crosstalk and common mechanisms of endocrine disruptors: Scaffolding to improve PBPK/PD model of EDC mixture.
TL;DR: A conceptual model of pharmacodynamic interaction is proposed to integrate the crosstalk and common mechanisms that modulate estrogen into the predictive mixture dosimetry model with dynamic interaction of mixture and can be used to develop next generation PBPK/PD models for EDCs' mixture analysis.
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Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function
Magda Dubińska-Magiera,Małgorzata Daczewska,Anna Lewicka,Marta Migocka-Patrzałek,Joanna Niedbalska-Tarnowska,Krzysztof Jagla +5 more
TL;DR: This review focuses on the reports concerning the application of zebrafish as a model for assessing the impact of toxicants on skeletal muscles, which share many structural and functional similarities among vertebrates, including zebra fish and humans.
References
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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.