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Journal ArticleDOI

Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects

Beverly S. Rubin
- 01 Oct 2011 - 
- Vol. 127, Iss: 1, pp 27-34
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.
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This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.

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Citations
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Journal ArticleDOI

BPA-free high-performance sustainable polycarbonates derived from non-estrogenic bio-based phenols

TL;DR: In this paper, the estrogenic activity of nine bio-based tris/bisphenols derived from resveratrol (1 and 2), anethole (3, 4), eugenol (5), carvacrol (6), and creosol (7, 9) was evaluated.
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Biobased thermally-stable aromatic cyanate ester thermosets: A review

TL;DR: A review of the recent progress on the synthesis methods, structure-property relationship, and applications of biobased cyanate ester polymer and discusses the future use of bioresources to produce such thermosets can be found in this article.
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Biomolecularly stimuli-responsive tetra-poly(ethylene glycol) that undergoes sol–gel transition in response to a target biomolecule

TL;DR: In this paper, the phase diagram of the sol-gel transition of a four-armed poly(ethylene glycol) (biotinylated Tetra-PEG) was presented.
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A high throughput method for measuring cloth-air equilibrium distribution ratios for SVOCs present in indoor environments.

TL;DR: It is demonstrated that the cloth-air equilibrium distribution ratio for species i, KCA_i, can be measured relatively easily and quickly using headspace analysis of cloth dosed with two common indoor air SVOCs, diethyl phthalate (DEP) and di-n-butyl phhalate (DnBP).
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Effects of High-Butterfat Diet on Embryo Implantation in Female Rats Exposed to Bisphenol A

TL;DR: The implantation disruptive effects of maternal exposure to an environmentally relevant dose of BPA are revealed and HBF diet is identified as a modifier of B PA in promoting early embryonic health.
References
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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).

TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004

TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption

TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.

TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.
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