Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
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Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey
Patricia A. Hunt,Crystal Lawson,Mary C. Gieske,Brenda M. Murdoch,Helen Smith,Alyssa Marre,Terry J. Hassold,Catherine A. VandeVoort +7 more
TL;DR: Results in the rhesus monkey indicate that BPA induces subtle disturbances in the prophase events that set the stage for chromosome segregation at the first meiotic division, and raises concerns for human reproductive health.
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Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012
Hanne Frederiksen,Tina Kold Jensen,Niels Jørgensen,Henriette Boye Kyhl,Steffen Husby,N E Skakkebaek,K M Main,Anders Juul,Anna-Maria Andersson +8 more
TL;DR: It is shown that nearly all Danes were exposed to the six most common phthalates, to BPA, TCS, and BP-3, and to at least two of the parabens, and the exposure to other non-persistent chemicals was also widespread.
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Human exposures to bisphenol A: mismatches between data and assumptions.
TL;DR: Evidence is addressed that challenges the assumption that humans metabolize BPA rapidly enough to result in undetectable levels in blood and therefore it is determined that there is a possibility of harm from current exposure levels.
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Sensors and biosensors for analysis of bisphenol-A
TL;DR: In this paper, state-of-the-art sensing methods for the detection of bisphenol-A (BPA), a well-known and much studied contaminant causing a wide range of health problems to living beings especially the young, are discussed.
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Micro- and nanoplastic induced cellular toxicity in mammals: A review
TL;DR: This review discusses the potential routes of exposure to micro- and nanoplastics, biological effects of these particles in mammalian cells, factors influencing toxicity, and the probable mechanisms of cytotoxicity.
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Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.