Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
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Journal ArticleDOI
Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.
Aurélie Vega,Emmanuelle Martinot,Marine Baptissart,Angélique de Haze,Jean-Paul Saru,Silvère Baron,Françoise Caira,Kristina Schoonjans,Jean-Marc A. Lobaccaro,David H. Volle +9 more
TL;DR: A new link between hypothalamo-pituitary axis and NR0B2 in testicular androgen metabolism is demonstrated, making NR0b2 a major actor of testicular physiology in case of alteration of LH/CG levels.
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BPA Replacement Compounds: Current Status and Perspectives
TL;DR: A large number of BPA replacement compounds have been introduced into the industry since growing evidence has manifested that bisphenol A (BPA) may adversely affect human health.
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Electrochemical detection and simultaneous removal of endocrine disruptor, bisphenol A using a carbon felt electrode
Min-Soo Kim,Young Eun Song,Jiu Qiang Xiong,Kyoung Yeol Kim,Min Jang,Byong-Hun Jeon,Jung Rae Kim +6 more
TL;DR: In this article, the BPA was detected by cyclic voltammetry and the peak current and BPA concentration showed a linear correlation; the estimated detection limit was 4.78 × 10−7 M. The BPA-electropolymerized carbon felt could be regenerated successfully by ultrasonication.
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Genotoxic potential of bisphenol A: A review.
TL;DR: In this paper , a review of the genotoxic effects of BPA on organisms across all taxa is presented, including single-and double-strand DNA breaks and increased intracellular oxidation.
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Electrochemical behavior of the endocrine disruptor bisphenol A and in situ investigation of its interaction with DNA
Hoda Ezoji,Mostafa Rahimnejad +1 more
TL;DR: In this paper, a sensitive, eco-friendly voltammetric method was developed to electrochemically monitor endocrine disruptor, bisphenol A (BPA) as well as the bio-interaction between DNA and BPA.
References
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Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.