Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
Reads0
Chats0
TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
More filters
Journal ArticleDOI
Developing in vitro reporter gene assays to assess the hormone receptor activities of chemicals frequently detected in drinking water
TL;DR: Results implied that the transcription activation mediated by hormone receptors was the potential endocrine‐disrupting mechanism of the test chemicals.
Journal ArticleDOI
Bisphenol S and Bisphenol A disrupt morphogenesis of MCF-12A human mammary epithelial cells.
TL;DR: It is shown that BPS and BPA are environmental pollutants that may affect mammary development and may contribute to the development of breast cancer.
Journal ArticleDOI
Bisphenol A Disrupts HNF4α-Regulated Gene Networks Linking to Prostate Preneoplasia and Immune Disruption in Noble Rats.
TL;DR: The findings suggest that the adult rat prostate, under a physiologically relevant T environment, is susceptible to BPA-induced transcriptomic reprogramming, immune disruption, and aberrant growth dysregulation in a manner distinct from those caused by E2.
Journal ArticleDOI
Long-term bisphenol A exposure exacerbates diet-induced prediabetes via TLR4-dependent hypothalamic inflammation.
Qinlong Ma,Ping Deng,Min Lin,Lingling Yang,Le Li,Lu Guo,Lei Zhang,Mindi He,Yonghui Lu,Huifeng Pi,Yanwen Zhang,Zhengping Yu,Chunhai Chen,Zhou Zhou +13 more
TL;DR: A key role is established for TLR4-dependent hypothalamic inflammation in regulating the effects of BPA on prediabetes, which is found to exacerbate HFD-induced prediabetic symptoms and eliminate inflammation by toll-like receptor 4 (TLR4) knockout.
Journal ArticleDOI
Adsorption Characteristics of Bisphenol A from Aqueous Solution onto HDTMAB-Modified Palygorskite
TL;DR: Hexadecyl trimethylammonium bromide (HDTMAB)-modified palygorskite with ultrasonic treatment was synthesized, characterized, and examined as a potential adsorbent for removal of bisphenol A (BPA) from aqueous solution.
References
More filters
Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Journal ArticleDOI
Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
Journal ArticleDOI
Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
Journal ArticleDOI
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Journal ArticleDOI
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.