Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
Reads0
Chats0
TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
More filters
Journal ArticleDOI
A plurality of molecular targets: The receptor ecosystem for bisphenol-A (BPA).
Harry MacKay,Alfonso Abizaid +1 more
TL;DR: The receptors for which BPA has a known interaction are reviewed, and the implications of taking these receptors into account when studying the disruptive effects of BPA on growth and development are discussed.
Journal ArticleDOI
Endocrine disruptors: New players in the pathophysiology of type 2 diabetes?
TL;DR: In this review, both in vivo and in vitro experimental data and epidemiological evidence to support an association between EDC exposure and the induction of insulin resistance and/or disruption of pancreatic β-cell function are summarized, while the epidemiological links with disorders of glucose homoeostasis are also discussed.
Journal ArticleDOI
Modulation of cytokine expression in human macrophages by endocrine-disrupting chemical Bisphenol-A.
TL;DR: It is identified that activation of extracellular regulated protein kinases (ERK)/nuclear factor κB (NF-κB) signal cascade marked the effects of BPA on cytokines expression and provided a new insight into the link between exposure to BPA and human health.
Journal ArticleDOI
NIEHS/FDA CLARITY-BPA research program update
Jerrold J. Heindel,Retha R. Newbold,John R. Bucher,Luísa Camacho,K. Barry Delclos,Sherry M. Lewis,Michelle Vanlandingham,Mona I. Churchwell,Nathan C. Twaddle,Michelle McLellen,Mani Chidambaram,Matthew Bryant,Kellie A. Woodling,Gonçalo Gamboa da Costa,Sherry A. Ferguson,Jodi A. Flaws,Paul C. Howard,Nigel J. Walker,R. Thomas Zoeller,Jennifer Fostel,Carolyn Favaro,Thaddeus T. Schug +21 more
TL;DR: A detailed description of the conduct of the study is provided and a midterm update on progress of the CLARITY-BPA research program is provided.
Journal ArticleDOI
Development and validation of LC-MS/MS method for quantification of bisphenol A and estrogens in human plasma and seminal fluid
Jana Vitku,Tereza Chlupacova,Lucie Sosvorova,Richard Hampl,Martin Hill,Jiri Heracek,Marie Bičíková,Luboslav Stárka +7 more
TL;DR: To the best of the knowledge, this is the first method that enabled the measurement of estrogens and BPA together in one run and the concentrations of E1, E2 and for the first time also of E3 in seminal plasma in normospermic men are reported.
References
More filters
Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Journal ArticleDOI
Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
Journal ArticleDOI
Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
Journal ArticleDOI
Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Journal ArticleDOI
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.