Journal ArticleDOI
Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects
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TLDR
Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01. It has received 1076 citations till now. The article focuses on the topics: Environmental exposure & Endocrine disruptor.read more
Citations
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Bisphenol AF promotes estrogen receptor-positive breast cancer cell proliferation through amphiregulin-mediated crosstalk with receptor tyrosine kinase signaling
TL;DR: The novel finding that AREG mediates BPAf-induced ER-RTK crosstalk in ER+ breast cancer cells supports future studies to characterize the impact of BPAF on human ER+ Breast cancer risk and to assess the safety profile of B PAF.
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Simultaneous Quantitative Assessment of Ochratoxin A, Patulin, 5-Hydroxymethylfurfural, and Bisphenol A in Fruit Drinks Using HPLC with Diode Array-Fluorimetric Detection.
Norfarizah Hanim Hassan,Haneen Ibrahim Ahmad Al Othman,Nur Rabiatutadawiah Abdul Malek,Musfirah Zulkurnain,Bahruddin Saad,Yong Foo Wong +5 more
TL;DR: The developed multi-contaminants analysis method was successfully applied to determine OTA, PAT, HMF, and BPA in various fruit drinks.
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Correlation between conjugated bisphenol a concentrations and efflux transporter expression in human fetal livers
Jamie E. Moscovitz,Muna S. Nahar,Stuart L. Shalat,Angela L. Slitt,Dana C. Dolinoy,Lauren M. Aleksunes +5 more
TL;DR: Data demonstrate that xenobiotic transporters may be coordinately expressed in the human fetal liver, and is the first report of a relationship between environmentally relevant fetal BPA levels and differences in the expression of transporter that can excrete the parent compound and its metabolites.
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Solid phase extraction and spectrofluorometric determination of leached bisphenol A from some polycarbonate products under simulated use conditions using surface molecularly imprinted magnetite nanospheres
TL;DR: In this article, a novel magnetic nanoadsorbent for solid phase extraction of leached bisphenol A (BPA) from some polycarbonate products is presented.
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Short-term induction of vitellogenesis in the immature male yellowfin seabream (Acanthopagrus latus) exposed to bisphenol A and 17β-estradiol:
TL;DR: It is demonstrated that short-term exposure of yellowfin seabream to BPA induced adverse effects in the reproductive system of hermaphrodite fish.
References
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Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
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Human exposure to bisphenol A (BPA).
TL;DR: The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models.
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Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
TL;DR: Urine concentrations of total BPA differed by race/ethnicity, age, sex, and household income, and these first U.S. population representative concentration data for urinary BPA and tOP should help guide public health research priorities.
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
TL;DR: This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.