Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank : a Mendelian randomization study
Susanna C. Larsson,Susanna C. Larsson,Magnus Bäck,Magnus Bäck,Jessica M. B. Rees,Jessica M. B. Rees,Amy M. Mason,Stephen Burgess +7 more
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TLDR
Evidence is provided that higher BMI and particularly fat mass index are associated with increased risk of aortic valve stenosis and most other cardiovascular conditions, and the roles of fat mass and fat-free mass on the same outcomes are assessed.Abstract:
Aims: The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mas ...read more
Citations
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Journal ArticleDOI
Guidelines for performing Mendelian randomization investigations.
Stephen Burgess,George Davey Smith,Neil M Davies,Frank Dudbridge,Dipender Gill,M. Maria Glymour,Fernando Pires Hartwig,Fernando Pires Hartwig,Michael V. Holmes,Michael V. Holmes,Cosetta Minelli,Caroline L Relton,Evropi Theodoratou,Evropi Theodoratou +13 more
TL;DR: The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses, data presentation, and interpretation.
Journal ArticleDOI
Poor Long-Term Survival in Patients With Moderate Aortic Stenosis
Geoff Strange,Simon Stewart,David S. Celermajer,David L. Prior,Gregory M. Scalia,Thomas H. Marwick,Marcus Ilton,Majo X. Joseph,Jim Codde,David Playford +9 more
TL;DR: These unique data confirm that when left untreated, severe aortic stenosis is associated with poor long-term survival and also suggest poor survival rates in patients with moderate AS.
Journal ArticleDOI
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
Veronika Skrivankova,Rebecca C Richmond,Benjamin Woolf,Neil M Davies,Neil M Davies,Sonja A. Swanson,Tyler J. VanderWeele,Nicholas J. Timpson,Julian P T Higgins,Niki Dimou,Claudia Langenberg,Claudia Langenberg,Elizabeth Loder,Robert M. Golub,Matthias Egger,Matthias Egger,Matthias Egger,George Davey Smith,J. Brent Richards,J. Brent Richards +19 more
TL;DR: The STROBE-MR (Strengthening the reporting of observational studies in epidemiology using mendelian randomisation) as mentioned in this paper ) is a set of guidelines that assist in reporting their research clearly and transparently.
Journal ArticleDOI
Obesity Cardiomyopathy: Evidence, Mechanisms and Therapeutic Implications.
TL;DR: In this article, a review of the evidence for obesity cardiomyopathy is presented, examining putative responsible mechanisms, and discusses therapeutic options for this disorder, which develops independent of hypertension, coronary heart disease, and other heart diseases.
Journal ArticleDOI
Inflammation and Premature Ageing in Chronic Kidney Disease
Thomas Ebert,Sven-Christian Pawelzik,Anna Witasp,Samsul Arefin,Sam Hobson,Karolina Kublickiene,Paul G. Shiels,Magnus Bäck,Magnus Bäck,Peter Stenvinkel +9 more
TL;DR: Treatment strategies targeting inflammation and premature ageing in CKD are of particular interest, and the endocrine phosphate-fibroblast growth factor-23–klotho axis, increased cellular senescence, and impaired mitochondrial biogenesis are currently the most promising candidates.
References
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Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Y.M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W M Monique Verschuren +25 more
TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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Cathie Sudlow,John Gallacher,Naomi E. Allen,Valerie Beral,Paul Burton,John Danesh,Paul Downey,Paul Elliott,Jane Green,Martin J Landray,Bette Liu,Paul M. Matthews,Giok Ong,Jill P. Pell,Alan J. Silman,Alan Young,Tim Sprosen,Tim Peakman,Rory Collins +18 more
TL;DR: The UK Biobank is described, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age.
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TL;DR: The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence‐based interventions to address this problem.
Journal ArticleDOI
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja-Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Yvo M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W. M. Monique Verschuren +25 more
TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.
Journal ArticleDOI
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?
George Davey Smith,Shah Ebrahim +1 more
TL;DR: Mendelian randomization provides new opportunities to test causality and demonstrates how investment in the human genome project may contribute to understanding and preventing the adverse effects on human health of modifiable exposures.
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