Journal ArticleDOI
Brain atrophy and cognition: interaction with cerebrovascular pathology?
Majon Muller,Auke P.A. Appelman,Yolanda van der Graaf,Koen L. Vincken,Willem P.Th.M. Mali,Mirjam I. Geerlings +5 more
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TLDR
Patients with cerebrovascular pathology on MRI may be more vulnerable to impairment in executive functioning related to global as well as focal brain atrophy, according to the findings of the SMART-MR study.About:
This article is published in Neurobiology of Aging.The article was published on 2011-05-01. It has received 80 citations till now. The article focuses on the topics: Brain segmentation & Hyperintensity.read more
Citations
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Hypertension and longitudinal changes in cerebral blood flow: The SMART-MR study
Majon Muller,Majon Muller,Yolanda van der Graaf,Frank L.J. Visseren,Willem P.Th.M. Mali,Mirjam I. Geerlings +5 more
TL;DR: Cerebral hypoperfusion is among the mechanisms that may explain the association of high blood pressure (BP) with dementia, however, few data are available on the longitudinal association of hypertension and cerebral perfusion.
Journal ArticleDOI
Cerebral Small Vessel Disease.
TL;DR: The pathophysiology, clinical aspects, neuroimaging, progress of research to treat and prevent CSVD and current treatment of this disease are discussed.
Journal ArticleDOI
Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study.
Hanna Jokinen,Jari Lipsanen,R. Schmidt,Franz Fazekas,Alida A. Gouw,W.M. van der Flier,Frederik Barkhof,Sofia Madureira,Ana Verdelho,José M. Ferro,Anders Wallin,Leonardo Pantoni,Domenico Inzitari,Timo Erkinjuntti +13 more
TL;DR: In this paper, the authors examined the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion (WML) volume in longitudinal cognitive performance.
Journal ArticleDOI
The concept of sporadic cerebral small vessel disease: A road map on key definitions and current concepts.
TL;DR: Modern neuroimaging has revolutionized the authors' understanding of the consequences of small vessels disease on the brain parenchyma, even though small arteries, arterioles, capillaries, and venules are difficult to be directly visualized with current techniques used in clinical practice.
Journal ArticleDOI
Vascular Imaging abnormalities and cognition: Mediation by cortical volume in nondemented individuals: Atherosclerosis risk in communities-neurocognitive study
David S. Knopman,Michael Griswold,Seth T. Lirette,Rebecca F. Gottesman,Kejal Kantarci,A. Richey Sharrett,Clifford R. Jack,Jonathan Graff-Radford,Andrea L.C. Schneider,B. Gwen Windham,Laura H. Coker,Marilyn S. Albert,Thomas H. Mosley +12 more
TL;DR: Both WMH and infarcts were associated with cortical volume, and both lesions were also associated with cognitive performance, implying shared pathophysiological mechanisms, which suggest that WMH could be proxies for clinically covert processes that directly damage cortical regions.
References
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Journal ArticleDOI
The cardiovascular health study: Design and rationale
Linda P. Fried,Nemat O. Borhani,Paul L. Enright,Curt D. Furberg,Julius M. Gardin,Richard A. Kronmal,Lewis H. Kuller,Teri A. Manolio,Maurice B. Mittelmark,Anne B. Newman,Daniel H. O'Leary,Bruce M. Psaty,Pentti M. Rautaharju,Russell P. Tracy,Philip G. Weiler +14 more
TL;DR: These examinations in CHS permit evaluation of CVD risk factors in older adults, particularly in groups previously under-represented in epidemiologic studies, such as women and the very old.
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Brain Infarction and the Clinical Expression of Alzheimer Disease: The Nun Study
David A. Snowdon,Lydia H. Greiner,James A. Mortimer,Kathryn P. Riley,Philip A. Greiner,William R. Markesbery +5 more
TL;DR: Findings suggest that cerebrovascular disease may play an important role in determining the presence and severity of the clinical symptoms of AD.
Journal ArticleDOI
National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards
Vladimir Hachinski,Costantino Iadecola,R. C. Petersen,Monique M.B. Breteler,David L. Nyenhuis,Sandra E. Black,William J. Powers,Charles DeCarli,José G. Merino,Raj N. Kalaria,Harry V. Vinters,David M. Holtzman,Gary A. Rosenberg,Martin Dichgans,John R. Marler,Gabrielle G. Leblanc +15 more
TL;DR: Using the same standards will help identify individuals in the early stages of cognitive impairment, will make studies comparable, and by integrating knowledge, will accelerate the pace of progress.
Journal ArticleDOI
Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
TL;DR: MRI scans of 92 nondemented older adults in the Baltimore Longitudinal Study of Aging provide essential information on the rate and regional pattern of age-associated changes against which pathology can be evaluated and suggest slower rates of brain atrophy in individuals who remain medically and cognitively healthy.
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Pathogenesis of Leukoaraiosis A Review
Leonardo Pantoni,Julio H. Garcia +1 more
TL;DR: A significant number of clues support the hypothesis that some types of leukoaraiosis may be the result of ischemic injury to the brain and this hypothesis could be tested in appropriate experimental models.
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