Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography
Sarah M. Friedewald,Elizabeth A. Rafferty,Stephen L. Rose,Melissa A. Durand,Donna Plecha,Julianne S. Greenberg,Mary Katherine Hayes,Debra S. Copit,Kara L. Carlson,Thomas M. Cink,Lora D. Barke,Linda N. Greer,Dave P. Miller,Emily F. Conant +13 more
TLDR
Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate, and further studies are needed to assess the relationship to clinical outcomes.Abstract:
mammography + tomosynthesis; difference, 1.3 (95% CI, 0.4-2.1; P = .004); for cancer detection, 4.2 (95% CI, 3.8-4.7) with digital mammography vs 5.4 (95% CI, 4.9-6.0) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001); and for invasive cancer detection, 2.9 (95% CI, 2.5-3.2) with digital mammography vs 4.1 (95% CI, 3.7-4.5) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001). The in situ cancer detection rate was 1.4 (95% CI, 1.2-1.6) per 1000 screens with both methods. Adding tomosynthesis was associated with an increase in the positive predictive value for recall from 4.3% to 6.4% (difference, 2.1%; 95% CI, 1.7%-2.5%; P < .001) and for biopsy from 24.2% to 29.2% (difference, 5.0%; 95% CI, 3.0%-7.0%; P < .001). CONCLUSIONS AND RELEVANCE Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate. Further studies are needed to assess the relationship to clinical outcomes.read more
Citations
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Benign to Malignant Spectrum of Architectural Distortions on Digital Breast Tomosynthesis
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Digital Breast Tomosynthesis: Clinical Operations
TL;DR: Understanding the DICOM standard for DBT, as well as how images are displayed, is critical to a successful transition, and adherence to DBT-specific parameters will enhance the physician experience and ultimately translate to increased cancer detection and fewer false positive examinations, benefiting all women who are screened for breast cancer.
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Brustkrebsfrüherkennung durch Mammographiescreening
TL;DR: There is a decrease in advanced tumor stages and due to the development of this surrogate parameter a substantial reduction in breast cancer mortality is to be expected and an exemplifying overview of essential quality assurance measures for the evaluation of program effectiveness is provided.
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Krebsfrüherkennung des Zervix- und des Mammakarzinoms
TL;DR: Screening programs for cervical cancer and breast cancer lead to a clear reduction of mortality and weighing the benefits against the harms of cancer screening programs is always important in the process of evaluation of different strategies.
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Tomosynthesis-guided Vacuum-assisted Breast Biopsy of Sonographically Occult Non-calcified Breast Lesions Detected on Tomosynthesis
TL;DR: Tomosynthesis-guided VAB is a safe and effective method for evaluation of sonographically occult lesions detected on digital breast tomosynthesis (DBT) and the feature associated with the majority of these lesions was architectural distortion.
References
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American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography
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Etta D. Pisano,Constantine Gatsonis,Edward Hendrick,Martin J. Yaffe,Janet K. Baum,Suddhasatta Acharyya,Emily F. Conant,Laurie L. Fajardo,Lawrence W. Bassett,Roberta A. Jong,Murray Rebner +10 more
TL;DR: The overall diagnostic accuracy of digital and film mammography as a means of screening for breast cancer is similar, but digital mammography is more accurate in women under the age of 50 years, women with radiographically dense breasts, and premenopausal or perimenopausal women.
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TL;DR: The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer.
Journal ArticleDOI
Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.
Wendie A. Berg,Jeffrey D. Blume,Jean B. Cormack,Ellen B. Mendelson,Daniel Lehrer,M. Böhm-Vélez,Etta D. Pisano,Roberta A. Jong,W. Phil Evans,Marilyn J. Morton,Mary C. Mahoney,Linda Hovanessian Larsen,Richard G. Barr,Dione M. Farria,Helga S. Marques,Karan Boparai +15 more
TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.