Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography
Sarah M. Friedewald,Elizabeth A. Rafferty,Stephen L. Rose,Melissa A. Durand,Donna Plecha,Julianne S. Greenberg,Mary Katherine Hayes,Debra S. Copit,Kara L. Carlson,Thomas M. Cink,Lora D. Barke,Linda N. Greer,Dave P. Miller,Emily F. Conant +13 more
TLDR
Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate, and further studies are needed to assess the relationship to clinical outcomes.Abstract:
mammography + tomosynthesis; difference, 1.3 (95% CI, 0.4-2.1; P = .004); for cancer detection, 4.2 (95% CI, 3.8-4.7) with digital mammography vs 5.4 (95% CI, 4.9-6.0) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001); and for invasive cancer detection, 2.9 (95% CI, 2.5-3.2) with digital mammography vs 4.1 (95% CI, 3.7-4.5) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001). The in situ cancer detection rate was 1.4 (95% CI, 1.2-1.6) per 1000 screens with both methods. Adding tomosynthesis was associated with an increase in the positive predictive value for recall from 4.3% to 6.4% (difference, 2.1%; 95% CI, 1.7%-2.5%; P < .001) and for biopsy from 24.2% to 29.2% (difference, 5.0%; 95% CI, 3.0%-7.0%; P < .001). CONCLUSIONS AND RELEVANCE Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate. Further studies are needed to assess the relationship to clinical outcomes.read more
Citations
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Journal ArticleDOI
Comparative effectiveness of combined digital mammography and tomosynthesis screening for women with dense breasts.
Christoph I. Lee,Mucahit Cevik,Oguzhan Alagoz,Brian L. Sprague,Anna N. A. Tosteson,Diana L. Miglioretti,Karla Kerlikowske,Natasha K. Stout,Jeffrey G. Jarvik,Scott D. Ramsey,Scott D. Ramsey,Constance D. Lehman,Constance D. Lehman +12 more
TL;DR: Biennial combined digital mammography and tomosynthesis screening for U.S. women aged 50-74 years with dense breasts is likely to be cost-effective if priced appropriately and if reported interpretive performance metrics of improved specificity with tomosynthetics are met in routine practice.
Journal ArticleDOI
Performance of breast cancer screening using digital breast tomosynthesis: results from the prospective population-based Oslo Tomosynthesis Screening Trial.
Per Skaane,Sofie Sebuødegård,Andriy I. Bandos,David Gur,Bjørn Helge Østerås,Randi Gullien,Solveig Hofvind +6 more
TL;DR: DBT-supplemented screening resulted in significant increases in screen-detected cancers and specificity, however, no significant change was observed in the rate, size, node status, or grade of interval cancers.
Journal ArticleDOI
Role of image thermography in early breast cancer detection- Past, present and future
TL;DR: This paper presents survey based on the main steps of computer aided detection systems: image acquisition protocols, segmentation techniques, feature extraction and classification methods, used in the field of breast thermography over the past few decades, and presents future recommendations to utilize recent machine learning advances in real time.
Journal ArticleDOI
Digital Breast Tomosynthesis with Synthesized Two-Dimensional Images versus Full-Field Digital Mammography for Population Screening: Outcomes from the Verona Screening Program
Francesca Caumo,Manuel Zorzi,Silvia Brunelli,Giovanna Romanucci,Rossella Rella,Loredana Cugola,Paola Bricolo,Chiara Fedato,Stefania Montemezzi,Nehmat Houssami +9 more
TL;DR: DBT plus synthetic 2D imaging increases CDRs with recall rates comparable to those of FFDM, and increased image reading time and the time needed for invasive assessments.
Journal ArticleDOI
Breast Cancer Screening for Women at Average Risk
TL;DR: There are multiple organizations with recommendations for breast cancer screening in women at average risk but differ in the age at which to initiate mammograms, screening interval, and the age in which to stop screening.
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TL;DR: The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer.
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TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.