Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography
Sarah M. Friedewald,Elizabeth A. Rafferty,Stephen L. Rose,Melissa A. Durand,Donna Plecha,Julianne S. Greenberg,Mary Katherine Hayes,Debra S. Copit,Kara L. Carlson,Thomas M. Cink,Lora D. Barke,Linda N. Greer,Dave P. Miller,Emily F. Conant +13 more
TLDR
Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate, and further studies are needed to assess the relationship to clinical outcomes.Abstract:
mammography + tomosynthesis; difference, 1.3 (95% CI, 0.4-2.1; P = .004); for cancer detection, 4.2 (95% CI, 3.8-4.7) with digital mammography vs 5.4 (95% CI, 4.9-6.0) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001); and for invasive cancer detection, 2.9 (95% CI, 2.5-3.2) with digital mammography vs 4.1 (95% CI, 3.7-4.5) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001). The in situ cancer detection rate was 1.4 (95% CI, 1.2-1.6) per 1000 screens with both methods. Adding tomosynthesis was associated with an increase in the positive predictive value for recall from 4.3% to 6.4% (difference, 2.1%; 95% CI, 1.7%-2.5%; P < .001) and for biopsy from 24.2% to 29.2% (difference, 5.0%; 95% CI, 3.0%-7.0%; P < .001). CONCLUSIONS AND RELEVANCE Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate. Further studies are needed to assess the relationship to clinical outcomes.read more
Citations
More filters
Journal ArticleDOI
Lobular breast cancer series: imaging
TL;DR: The evidence supporting the performance of each imaging modality as it relates to the pathology of invasive lobular carcinoma and its subtypes will be reviewed and emerging technologies that may be employed to enhance the detection rate and ultimately result in more effective screening and staging of ILC are discussed.
Journal ArticleDOI
Improving Accuracy and Efficiency with Concurrent Use of Artificial Intelligence for Digital Breast Tomosynthesis.
Emily F. Conant,Alicia Y. Toledano,Senthil Periaswamy,Sergei V. Fotin,Jonathan Go,Justin E. Boatsman,Jeffrey W. Hoffmeister +6 more
TL;DR: The concurrent use of an accurate DBT AI system was found to improve cancer detection efficacy in a reader study that demonstrated increases in AUC, sensitivity, and specificity and a reduction in recall rate and reading time.
Journal ArticleDOI
Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening: A Modeling Study
Diana L. Miglioretti,Jane M. Lange,Jeroen J. van den Broek,Christoph I. Lee,Nicolien T. van Ravesteyn,Dominique Ritley,Karla Kerlikowske,Joshua J. Fenton,Joy Melnikow,Harry J. de Koning,Rebecca A. Hubbard +10 more
TL;DR: In this paper, the authors estimate distributions of radiation-induced breast cancer incidence and mortality from digital mammography screening while considering exposure from screening and diagnostic mammography and dose variation among women.
Journal ArticleDOI
Digital Breast Tomosynthesis and Synthetic 2D Mammography versus Digital Mammography: Evaluation in a Population-based Screening Program
Solveig Hofvind,Tone Hovda,Åsne S Holen,Christoph I. Lee,Judy Lynn Albertsen,Hilde Bjørndal,Siri Helene Bertelsen Brandal,Randi Gullien,Jon Lømo,Daehoon Park,Linda Romundstad,Pål Suhrke,Einar Vigeland,Per Skaane +13 more
TL;DR: DBT and SM screening increased the detection rate of histologically favorable tumors compared with that attained with DM screening, and rates of lymph node involvement and tumor subtypes did not differ.
Journal ArticleDOI
Breast density implications and supplemental screening
Athina Vourtsis,Wendie A. Berg +1 more
TL;DR: The sensitivity of mammography is reduced in women with dense breasts and contrast-enhanced digital mammography (CEDM) and molecular breast imaging improve cancer detection but require further validation for screening and direct biopsy guidance should be implemented for any screening modality.
References
More filters
Journal ArticleDOI
American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography
Debbie Saslow,Carla Boetes,Wylie Burke,Steven E. Harms,Martin O. Leach,Constance D. Lehman,Elizabeth A. Morris,Etta D. Pisano,Mitchell D. Schnall,Stephen F. Sener,Robert A. Smith,Ellen Warner,Martin J. Yaffe,Kimberly S. Andrews,Christy A. Russell +14 more
TL;DR: There are several risk subgroups for which the available data are insufficient to recommend for or against screening, including women with a personal history of breast cancer, carcinoma in situ, atypical hyperplasia, and extremely dense breasts on mammography.
Journal ArticleDOI
Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement
TL;DR: Although lung cancer screening is not an alternative to smoking cessation, the USPSTF found adequate evidence that annual screening for lung cancer with LDCT in a defined population of high-risk persons can prevent a substantial number of lung cancerrelated deaths.
Journal ArticleDOI
Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening
Etta D. Pisano,Constantine Gatsonis,Edward Hendrick,Martin J. Yaffe,Janet K. Baum,Suddhasatta Acharyya,Emily F. Conant,Laurie L. Fajardo,Lawrence W. Bassett,Roberta A. Jong,Murray Rebner +10 more
TL;DR: The overall diagnostic accuracy of digital and film mammography as a means of screening for breast cancer is similar, but digital mammography is more accurate in women under the age of 50 years, women with radiographically dense breasts, and premenopausal or perimenopausal women.
Journal ArticleDOI
Screening for Breast Cancer: US Preventive Services Task Force Recommendation Statement
Ned Calonge,Diana B. Petitti,Thomas G. DeWitt,Allen J. Dietrich,Kimberly D. Gregory,David C. Grossman,George Isham,Michael L. LeFevre,Rosanne M. Leipzig,Lucy N. Marion,Bernadette Mazurek Melnyk,Virginia A. Moyer,Judith K. Ockene,George F. Sawaya,J. Sanford Schwartz,Timothy J Wilt,US Preventive Serv Task Force +16 more
TL;DR: The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer.
Journal ArticleDOI
Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.
Wendie A. Berg,Jeffrey D. Blume,Jean B. Cormack,Ellen B. Mendelson,Daniel Lehrer,M. Böhm-Vélez,Etta D. Pisano,Roberta A. Jong,W. Phil Evans,Marilyn J. Morton,Mary C. Mahoney,Linda Hovanessian Larsen,Richard G. Barr,Dione M. Farria,Helga S. Marques,Karan Boparai +15 more
TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.