Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography
Sarah M. Friedewald,Elizabeth A. Rafferty,Stephen L. Rose,Melissa A. Durand,Donna Plecha,Julianne S. Greenberg,Mary Katherine Hayes,Debra S. Copit,Kara L. Carlson,Thomas M. Cink,Lora D. Barke,Linda N. Greer,Dave P. Miller,Emily F. Conant +13 more
TLDR
Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate, and further studies are needed to assess the relationship to clinical outcomes.Abstract:
mammography + tomosynthesis; difference, 1.3 (95% CI, 0.4-2.1; P = .004); for cancer detection, 4.2 (95% CI, 3.8-4.7) with digital mammography vs 5.4 (95% CI, 4.9-6.0) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001); and for invasive cancer detection, 2.9 (95% CI, 2.5-3.2) with digital mammography vs 4.1 (95% CI, 3.7-4.5) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001). The in situ cancer detection rate was 1.4 (95% CI, 1.2-1.6) per 1000 screens with both methods. Adding tomosynthesis was associated with an increase in the positive predictive value for recall from 4.3% to 6.4% (difference, 2.1%; 95% CI, 1.7%-2.5%; P < .001) and for biopsy from 24.2% to 29.2% (difference, 5.0%; 95% CI, 3.0%-7.0%; P < .001). CONCLUSIONS AND RELEVANCE Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate. Further studies are needed to assess the relationship to clinical outcomes.read more
Citations
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Fully Automated Quantitative Estimation of Volumetric Breast Density from Digital Breast Tomosynthesis Images: Preliminary Results and Comparison with Digital Mammography and MR Imaging.
TL;DR: In this article, a fully automated method for the computation of quantitative volumetric breast density from digital breast tomosynthesis (DBT) images and demonstrates a comparison with volume-based measures from full-field mammography, DBT, and MR imaging.
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False positives in breast cancer screening with one-view breast tomosynthesis: An analysis of findings leading to recall, work-up and biopsy rates in the Malmö Breast Tomosynthesis Screening Trial
TL;DR: FPs increased with BT screening mainly due to the recall of stellate distortions, andTomosynthesis is better at characterising rounded lesions than mammography, and showed evidence of a learning curve.
Journal ArticleDOI
Improving digital breast tomosynthesis reading time: A pilot multi-reader, multi-case study using concurrent Computer-Aided Detection (CAD).
Corinne Balleyguier,Julia Arfi-Rouche,Laurent Lévy,Patrick R. Toubiana,Franck Cohen-Scali,Alicia Y. Toledano,Bruno Boyer +6 more
TL;DR: Conurrent CAD resulted in faster reading time with non-inferiority of radiologist interpretation performance, and sensitivity, specificity and recall rate were similar with and without CAD.
Journal ArticleDOI
BRCA Mutation Carriers: Breast and Ovarian Cancer Screening Guidelines and Imaging Considerations
Mai Elezaby,Brittany Lees,Katherine E. Maturen,Lisa Barroilhet,Kari B. Wisinski,Sarina Schrager,Lee G. Wilke,Elizabeth A. Sadowski +7 more
TL;DR: This monograph summarizes the evidence behind current screening recommendations, reviews imaging protocols specific to this patient population, and illustrates some of the imaging nuances of breast and ovarian cancers in this clinical setting.
Journal ArticleDOI
Long-Term Outcomes and Cost-Effectiveness of Breast Cancer Screening With Digital Breast Tomosynthesis in the United States
Kathryn P. Lowry,Amy Trentham-Dietz,Clyde B. Schechter,Oguzhan Alagoz,William E. Barlow,Elizabeth S. Burnside,Emily F. Conant,John M. Hampton,Hui Huang,Karla Kerlikowske,Sandra J. Lee,Diana L. Miglioretti,Diana L. Miglioretti,Brian L. Sprague,Anna N.A. Tosteson,Martin J. Yaffe,Natasha K. Stout +16 more
TL;DR: DBT reduces false-positive exams while achieving similar or slightly improved health benefits; however, DBT could be cost-effective at lower screening costs.
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Etta D. Pisano,Constantine Gatsonis,Edward Hendrick,Martin J. Yaffe,Janet K. Baum,Suddhasatta Acharyya,Emily F. Conant,Laurie L. Fajardo,Lawrence W. Bassett,Roberta A. Jong,Murray Rebner +10 more
TL;DR: The overall diagnostic accuracy of digital and film mammography as a means of screening for breast cancer is similar, but digital mammography is more accurate in women under the age of 50 years, women with radiographically dense breasts, and premenopausal or perimenopausal women.
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TL;DR: The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer.
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Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.
Wendie A. Berg,Jeffrey D. Blume,Jean B. Cormack,Ellen B. Mendelson,Daniel Lehrer,M. Böhm-Vélez,Etta D. Pisano,Roberta A. Jong,W. Phil Evans,Marilyn J. Morton,Mary C. Mahoney,Linda Hovanessian Larsen,Richard G. Barr,Dione M. Farria,Helga S. Marques,Karan Boparai +15 more
TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.