Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography
Sarah M. Friedewald,Elizabeth A. Rafferty,Stephen L. Rose,Melissa A. Durand,Donna Plecha,Julianne S. Greenberg,Mary Katherine Hayes,Debra S. Copit,Kara L. Carlson,Thomas M. Cink,Lora D. Barke,Linda N. Greer,Dave P. Miller,Emily F. Conant +13 more
TLDR
Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate, and further studies are needed to assess the relationship to clinical outcomes.Abstract:
mammography + tomosynthesis; difference, 1.3 (95% CI, 0.4-2.1; P = .004); for cancer detection, 4.2 (95% CI, 3.8-4.7) with digital mammography vs 5.4 (95% CI, 4.9-6.0) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001); and for invasive cancer detection, 2.9 (95% CI, 2.5-3.2) with digital mammography vs 4.1 (95% CI, 3.7-4.5) with digital mammography + tomosynthesis; difference, 1.2 (95% CI, 0.8-1.6; P < .001). The in situ cancer detection rate was 1.4 (95% CI, 1.2-1.6) per 1000 screens with both methods. Adding tomosynthesis was associated with an increase in the positive predictive value for recall from 4.3% to 6.4% (difference, 2.1%; 95% CI, 1.7%-2.5%; P < .001) and for biopsy from 24.2% to 29.2% (difference, 5.0%; 95% CI, 3.0%-7.0%; P < .001). CONCLUSIONS AND RELEVANCE Addition of tomosynthesis to digital mammography was associated with a decrease in recall rate and an increase in cancer detection rate. Further studies are needed to assess the relationship to clinical outcomes.read more
Citations
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Journal ArticleDOI
Detection Rates for Benign and Malignant Diagnoses on Breast Cancer Screening With Digital Breast Tomosynthesis in a Statewide Mammography Registry Study.
Mayo H. Fujii,Sally D. Herschorn,Michelle Sowden,Elise L. Hotaling,Pamela M. Vacek,Donald L. Weaver,Brian L. Sprague +6 more
TL;DR: Compared with FFDM, breast cancer screening with DBT has a lower recall rate while detecting a similar distribution of benign and malignant diagnoses.
Journal ArticleDOI
Tomosynthesis-Guided Core Biopsy of the Breast: Why and How to Use it
TL;DR: Management challenges and dilemmas that are encountered with abnormalities detected on DBT and lacking a sonographic correlate can now be addressed with tomosynthesis-guided core biopsy.
Journal ArticleDOI
Monte Carlo study on optimal breast voxel resolution for dosimetry estimates in digital breast tomosynthesis
Christian Fedon,Carolina Rabin,Marco Caballo,Oliver Diaz,Eloy García,Alejandro Rodriguez-Ruiz,Gabriel A. González-Sprinberg,Ioannis Sechopoulos +7 more
TL;DR: This study investigates the optimal DBT reconstructed voxel size that allows accurate dose evaluations using a validated Geant4-based MC code and deformed patient-based breast models, previously acquired using dedicated breast computed tomography (BCT) images, to reproduce the breast during compression under a given DBT scenario.
Journal ArticleDOI
Trade-Offs Between Harms and Benefits of Different Breast Cancer Screening Intervals Among Low-Risk Women
Nicolien T. van Ravesteyn,Clyde B. Schechter,John M. Hampton,Oguzhan Alagoz,Jeroen J. van den Broek,Karla Kerlikowske,Jeanne S. Mandelblatt,Diana L. Miglioretti,Diana L. Miglioretti,Brian L. Sprague,Natasha K. Stout,Harry J. de Koning,Amy Trentham-Dietz,Anna N.A. Tosteson +13 more
TL;DR: In this paper, the authors examined screening harms and benefits among women aged 50-74 years at lower-than-average breast cancer risk by breast density, and found that for women with fatty or scattered fibroglandular breast density and a relative risk of no more than 0.85, the additional deaths averted and life-years gained were small with biennial vs triennial screening.
Journal ArticleDOI
Digital breast tomosynthesis plus mammography, magnetic resonance imaging plus mammography and mammography alone: a comparison of diagnostic performance in symptomatic women
TL;DR: The diagnostic performance of DBT and MRI combined with DM is superior to that of DM alone in symptomatic women; MRI plus DM is slightly better than that of D BT plus DM, but this difference was not statistically significant.
References
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TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.