Breast cancer subtypes predispose the site of distant metastases.
Abha Soni,Zhiyong Ren,Omar Hameed,Omar Hameed,Diptiman Chanda,Charity J. Morgan,Gene P. Siegal,Shi Wei +7 more
TLDR
Findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.Abstract:
Objectives: The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance.
Methods: We explored the relationship between the clinicopathologic factors and the common sites of distant metastasis in 531 consecutive patients with advanced breast cancer.
Results: Breast cancer subtype as a variable was significantly associated with all five common sites of relapse by multivariate analysis. The luminal tumors were remarkable for their significant bone-seeking phenotype and were less frequently observed in lung, brain, and pleural metastases and less likely to be associated with multiorgan relapse. The HER2 subtype demonstrated a significant liver-homing characteristic. African Americans were significantly less likely to have brain-only metastasis in patients with brain relapse.
Conclusions: These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.read more
Citations
More filters
Journal ArticleDOI
HER2-positive breast cancer
Sibylle Loibl,Luca Gianni +1 more
TL;DR: New treatments in the past decade have clearly improved the prognosis of HER2-positive breast cancer, however, the persisting high toll of deaths resulting from Her2- positive breast cancer calls for continued, intensive clinical research of newer therapies and combinations.
Journal ArticleDOI
Surviving at a Distance: Organ-Specific Metastasis
Anna C. Obenauf,Joan Massagué +1 more
TL;DR: This work reviews the metastatic traits that allow cancer cells to colonize distinct organ sites and the bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic colonization.
Journal ArticleDOI
Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study
TL;DR: The pathological subtypes of breast cancer are clearly different in metastatic behavior with regard to the sites of distant metastasis, emphasizing that this knowledge may help to determine the appropriate strategy for follow-up and guide personalized medicine.
Journal ArticleDOI
Breast cancer brain metastases: biology and new clinical perspectives.
TL;DR: The biology of breast cancer that has spread into the brain is summarized and the implications for current and potential future treatment strategies are discussed.
Journal ArticleDOI
Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer.
K.G.K. Deepak,Rahul Kumar Vempati,Ganji Purnachandra Nagaraju,Venkata Ramesh Dasari,Siddavaram Nagini,D.N. Rao,Rama Rao Malla +6 more
TL;DR: The current review presents latest updates on the role of exosomes in modulation of TME, approaches for targeting TME and combination of immune checkpoint inhibitors and target chemotherapeutics.
References
More filters
Journal ArticleDOI
Significance of estrogen and progesterone receptors, disease-free interval, and site of first metastasis on survival of breast cancer patients
TL;DR: In the patient group treated with endocrine therapy, ER and PR positivity was the best prognostic indicator, suggesting that longer survival in receptor positive patients was related to the response to endocrine treatment.
Journal ArticleDOI
Brain metastases of breast cancer.
Diane Palmieri,Quentin R. Smith,Paul R. Lockman,Julie L. Bronder,Brunilde Gril,Ann F. Chambers,Robert J. Weil,Patricia S. Steeg +7 more
TL;DR: Central nervous system or brain metastases traditionally occur in 10-16% of metastatic breast cancer patients and are associated with a dismal prognosis, so new therapies with permeability for the blood-brain barrier are needed to counteract both types of tumor cells.
Journal ArticleDOI
Steroid hormone receptor activity of primary human breast cancer and pattern of first metastasis
P. G. Koenders,L. V. A. M. Beex,R. Langens,Peter W. C. Kloppenborg,A. G. H. Smals,Th.J. Benraad +5 more
TL;DR: Multivariate analysis showed that the observed differences in metastatic patterns were all attributable to differences in the ER status of the primary tumour, and were not influenced by age, menopausal status, axillary lymph node involvement, duration of disease-free interval (DFI), mode of postoperative treatment, or the PgRstatus of thePrimary tumour.
Journal ArticleDOI
Heterogeneity of Breast Cancer Metastases: Comparison of Therapeutic Target Expression and Promoter Methylation Between Primary Tumors and Their Multifocal Metastases
Journal ArticleDOI
Interobserver concordance in implementing the 2010 ASCO/CAP recommendations for reporting ER in breast carcinomas: a demonstration of the difficulties of consistently reporting low levels of ER expression by manual quantification.
Emily Reisenbichler,Susan C. Lester,Andrea L. Richardson,Deborah A. Dillon,Amy Ly,Jane E. Brock +5 more
TL;DR: Discordance overwhelmingly reflected differing opinions recording the proportion of tumor cells positive with low levels of expression (<10% staining; 12/13 cases), an underappreciated clinically significant rate.
Related Papers (5)
Molecular portraits of human breast tumours
Charles M. Perou,Therese Sørlie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,Christian A. Rees,Jonathan R. Pollack,Douglas T. Ross,Hilde Johnsen,Lars A. Akslen,Øystein Fluge,Alexander Pergamenschikov,Cheryl A. Williams,Shirley Zhu,Per Eystein Lønning,Anne Lise Børresen-Dale,Patrick O. Brown,David Botstein +17 more