Breast cancer subtypes predispose the site of distant metastases.
Abha Soni,Zhiyong Ren,Omar Hameed,Omar Hameed,Diptiman Chanda,Charity J. Morgan,Gene P. Siegal,Shi Wei +7 more
TLDR
Findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.Abstract:
Objectives: The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance.
Methods: We explored the relationship between the clinicopathologic factors and the common sites of distant metastasis in 531 consecutive patients with advanced breast cancer.
Results: Breast cancer subtype as a variable was significantly associated with all five common sites of relapse by multivariate analysis. The luminal tumors were remarkable for their significant bone-seeking phenotype and were less frequently observed in lung, brain, and pleural metastases and less likely to be associated with multiorgan relapse. The HER2 subtype demonstrated a significant liver-homing characteristic. African Americans were significantly less likely to have brain-only metastasis in patients with brain relapse.
Conclusions: These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.read more
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Combination of anti‐PD‐L1 antibody with peptide MEL‐dKLA targeting M2 tumor‐associated macrophages suppresses breast cancer metastasis
FAYZIYEVA GULRUKH,Jing Zhao +1 more
TL;DR: In this article , a peptide named MEL-dKLA consisting of melittin, which bound preferentially to M2-like macrophages (TAMs), a short peptide bridge GGGGS, and pro-apoptotic peptide d(KLAKLAK)2 (DKLA).
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Clinicopathological Characteristics and Survival Outcomes in Patients with Synchronous Lung Metastases Upon Initial Metastatic Breast Cancer Diagnosis in Han Population
TL;DR: This study provides essential information on clinicopathological features and survival outcomes of BCLM patients at initial diagnosis of MBC in China.
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Skeletal impact of 17β-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation
TL;DR: It is demonstrated that bone effects of E 2 supplementation should be accounted for when assessing ER+ human xenograft bone metastases models and induced osteolytic osteosarcomas in a subset of mice independent of age.
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Liver Metastatic Breast Cancer: Epidemiology, Dietary Interventions, and Related Metabolism
TL;DR: There are no standard evidence-based recommendations for diet therapies before or during cancer treatment, and few studies provide definitive data that certain diets can mediate tumor progression or therapeutic effectiveness in human cancer.
Book ChapterDOI
Epidemiology of Central Nervous System Metastases
Linda Dirven,Martin J B Taphoorn +1 more
TL;DR: Understanding patterns in the incidence of brain metastases may guide clinicians in counselling individual patients in daily clinical practice, as prognosis of the underlying disease is a critical factor in treatment decision-making.
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TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study.
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TL;DR: Basal-like breast tumors occurred at a higher prevalence among premenopausal African American patients compared with postmenopausal American and non-African American patients in this population-based study, and their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer-specific survival were examined.
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Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
TL;DR: Broad treatment recommendations are presented, recognizing that detailed treatment decisions need to consider disease extent, host factors, patient preferences, and social and economic constraints.
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