Breast cancer subtypes predispose the site of distant metastases.
Abha Soni,Zhiyong Ren,Omar Hameed,Omar Hameed,Diptiman Chanda,Charity J. Morgan,Gene P. Siegal,Shi Wei +7 more
TLDR
Findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.Abstract:
Objectives: The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance.
Methods: We explored the relationship between the clinicopathologic factors and the common sites of distant metastasis in 531 consecutive patients with advanced breast cancer.
Results: Breast cancer subtype as a variable was significantly associated with all five common sites of relapse by multivariate analysis. The luminal tumors were remarkable for their significant bone-seeking phenotype and were less frequently observed in lung, brain, and pleural metastases and less likely to be associated with multiorgan relapse. The HER2 subtype demonstrated a significant liver-homing characteristic. African Americans were significantly less likely to have brain-only metastasis in patients with brain relapse.
Conclusions: These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.read more
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Malignant Pleural Effusion and Its Current Management: A Review.
TL;DR: A literature review of the newest findings, reviews of the guidelines and pathophysiological novelties, as well as analysis of more than 70 articles from the Pubmed, Medline databases that were almost exclusively published in indexed journals in the last few years, have relevance and contribute to the better understanding of the presented topic.
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Risk factors and survival outcomes in patients with breast cancer and lung metastasis: a population-based study.
TL;DR: Survition analysis showed that the aged, black race, HR−/her2+, triple‐negative subtype, higher grade were the independent risk factor for BCLM patients’ survival, while HR+/HER2+ sub type, insured status, and married status suggested better prognosis.
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Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis.
TL;DR: The role of the arachidonic acid metabolic pathway in BC metastasis is understood with an emphasis on 20-HETE as a novel therapeutic target to decreaseBC metastasis.
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Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon?
TL;DR: This review summarises currently available information on the risk factors predicting brain metastases in BC patients to motivate the relevant scientific areas to explore the data/facts available and elucidate disease-specific mechanisms that are of a great clinical utility.
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Management of brain metastases in breast cancer: a review of current practices and emerging treatments
Matthew N. Mills,Nicholas B Figura,John A. Arrington,Hsiang-Hsuan Michael Yu,Arnold B. Etame,Michael A. Vogelbaum,Hatem Soliman,Brian J. Czerniecki,Peter A. Forsyth,Hyo S. Han,Kamran Ahmed +10 more
TL;DR: Multidisciplinary management combining the strengths of surgical, systemic, and radiation treatment modalities with prospective trials incorporating knowledge from the basic and translational sciences will ultimately lead to improved clinical outcomes for BCBM patients.
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TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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TL;DR: Basal-like breast tumors occurred at a higher prevalence among premenopausal African American patients compared with postmenopausal American and non-African American patients in this population-based study, and their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer-specific survival were examined.
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Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
TL;DR: Broad treatment recommendations are presented, recognizing that detailed treatment decisions need to consider disease extent, host factors, patient preferences, and social and economic constraints.
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