Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory.
Reads0
Chats0
TLDR
This article aims to propose and support a concept of a triple brain network model of the dysfunctional switching between default mode and central executive network (CEN) related to the aberrant activity of the salience network and review previous studies which document the dysfunctions of self and ToM in schizophrenia.Abstract:
Schizophrenia is a complex neuropsychiatric disorder with variable symptomatology, traditionally divided into positive and negative symptoms, and cognitive deficits. Yet, the etiology of this disorder has yet to be fully understood.Recent findings suggest that alteration of the basic sense of self-awareness may be an essential distortion of schizophrenia spectrum disorders. In addition, extensive research of social and mentalizing abilities has stressed the role of distortion of social skills in schizophrenia.This article aims to propose and support a concept of triple brain network model of the dysfunctional switching between default mode and central executive network related to the aberrant activity of salience network. This model could represent a unitary mechanism of a wide array of symptom domains present in schizophrenia including the deficit of SELF (self-awareness and self-representation) and theory of mind (ToM) dysfunctions along with the traditional positive, negative and cognitive domains. We review previous studies which document the dysfunctions of SELF and ToM in schizophrenia together with neuroimaging data elucidating the triple brain network model as a common neuronal substrate of this dysfunction.read more
Citations
More filters
Journal ArticleDOI
Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment.
TL;DR: Clinical and experimental evidence for abnormalities in SN cortico-striatal-thalamic loop circuits in major depression, substance use disorders (SUD), anxiety disorders, schizophrenia and eating disorders (ED), and novel invasive and non-invasive brain stimulation treatments may exert therapeutic effects by normalizing abnormalities in the SN loop are reviewed.
Journal ArticleDOI
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
Rahul S. Desikan,Andrew J. Schork,Yunpeng Wang,Yunpeng Wang,Aree Witoelar,Manu Sharma,Linda K. McEvoy,Dominic Holland,James B. Brewer,Chi-Hua Chen,Thompson Wk,Denise Harold,Julie Williams,Michael John Owen,Michael Conlon O'Donovan,Margaret A. Pericak-Vance,Richard Mayeux,Jonathan L. Haines,Lindsay A. Farrer,Gerard D. Schellenberg,Peter Heutink,AB Singleton,Alexis Brice,Nicholas W. Wood,John Hardy,Maria Martinez,Seung Hoan Choi,Anita L. DeStefano,Anita L. DeStefano,M. A. Ikram,Joshua C. Bis,Anne H. Smith,Annette L. Fitzpatrick,Lenore J. Launer,C M van Duijn,Sudha Seshadri,Sudha Seshadri,Ingun Ulstein,Dag Aarsland,Dag Aarsland,Dag Aarsland,Tormod Fladby,Srdjan Djurovic,Bradley T. Hyman,Jon Snaedal,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,T. Gasser,Ole A. Andreassen,Ole A. Andreassen,Anders M. Dale +51 more
TL;DR: The tau-associated MAPT locus is identified as a site of genetic overlap between AD and PD and it is shown that the MAPT region increases risk of Alzheimer’s neurodegeneration.
Journal ArticleDOI
Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms.
Theodore D. Satterthwaite,Simon N. Vandekar,Daniel H. Wolf,Danielle S. Bassett,Kosha Ruparel,Zarrar Shehzad,Zarrar Shehzad,R C Craddock,R C Craddock,Russell T. Shinohara,Tyler M. Moore,Efstathios D. Gennatas,Chad T. Jackson,David R. Roalf,Michael P. Milham,Michael P. Milham,Monica E. Calkins,Hakon Hakonarson,Hakon Hakonarson,R.C. Gur,R.C. Gur,R.E. Gur +21 more
TL;DR: Evidence is found for multi-focal dysconnectivity in PS youths, implicating the bilateral anterior cingulate, frontal pole, medial temporal lobe, opercular cortex and right orbitofrontal cortex, which shows marked correspondence to abnormalities reported in adults with established psychotic disorders.
Journal ArticleDOI
Effects of Ketamine on Resting-State EEG Activity and Their Relationship to Perceptual/Dissociative Symptoms in Healthy Humans.
Joelle Choueiry,Dhrasti Shah,Hayley Bowers,Judy McIntosh,Vadim Ilivitsky,Vadim Ilivitsky,Verner Knott +6 more
TL;DR: The hypothesis that pathological brain oscillations associated with hypofunctional NMDA receptor activity may contribute to the emergence of the perceptual/dissociate symptoms of schizophrenia is tentatively supported.
Journal ArticleDOI
Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression.
Leonhard Schilbach,Felix Hoffstaedter,Veronika I. Müller,EC Cieslik,Roberto Goya-Maldonado,Sarah Trost,Christian Sorg,Valentin Riedl,Renaud Jardri,Iris E. C. Sommer,Lydia Kogler,Birgit Derntl,Oliver Gruber,Simon B. Eickhoff +13 more
TL;DR: Common dysconnectivity patterns are demonstrated as indexed by a significant reduction of functional connectivity between precuneus and bilateral superior parietal lobe in schizophrenia and depression, and diagnosis-specific connectivity reductions of the parietal operculum are highlighted.
References
More filters
Book
The Feeling of What Happens: Body and Emotion in the Making of Consciousness
TL;DR: The Feeling of What Happens as mentioned in this paper is a theory of the nature of consciousness and the construction of the self, which is the feeling of what happens-our mind noticing the body's reaction to the world and responding to that experience.
Journal ArticleDOI
Saliency, switching, attention and control: a network model of insula function
Vinod Menon,Lucina Q. Uddin +1 more
TL;DR: It is suggested that this framework provides a parsimonious account of insula function in neurotypical adults, and may provide novel insights into the neural basis of disorders of affective and social cognition.
Journal ArticleDOI
Meeting of minds: the medial frontal cortex and social cognition.
David M. Amodio,Chris D. Frith +1 more
TL;DR: This work reviews the emerging literature that relates social cognition to the medial frontal cortex and proposes a theoretical model of medial frontal cortical function relevant to different aspects of social cognitive processing.
Journal ArticleDOI
Theory of mind.
Chris D. Frith,Uta Frith +1 more
TL;DR: For example, Frith as discussed by the authors showed that children with autism have a specific problem with theory-of-mind tasks, such as looking for the hidden chocolate in the cupboard.
Book Chapter
Theory of Mind
TL;DR: Only from age five or so do children show full understanding of the situation and become able to explain exactly why Maxi has a false belief, and even 15-month-olds can be shown to have an inkling of what is going on.
Related Papers (5)
Saliency, switching, attention and control: a network model of insula function
Vinod Menon,Lucina Q. Uddin +1 more