Journal ArticleDOI
Bronchial epithelium as a target for innovative treatments in asthma.
TLDR
The dynamic processes regulating airway mucus production are discussed, which will require assessment of these epithelial abnormalities to identify phenotypic characteristics associated with predicting a clinical benefit for epithelial-directed therapies.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2013-12-01. It has received 107 citations till now. The article focuses on the topics: Respiratory epithelium & Airway.read more
Citations
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Journal ArticleDOI
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
TL;DR: Therapeutics which target NF-κB activation, including inhibitors of IκB kinases (IKKs) are potential treatments for asthma and COPD and reversing GR/histone acetylation shows promise as a strategy to treat steroid refractory airway disease by augmenting NF-σκB transrepression.
Journal ArticleDOI
The epithelium in idiopathic pulmonary fibrosis: breaking the barrier.
TL;DR: The role of the epithelium is described as both a physical and immunological barrier between environment and self in the homeostatic versus diseased lung and the impact of loss of epithelial cell permeability and function on cytokine production, inflammation, and myofibroblast activation in the fibrotic lung is explored.
Journal ArticleDOI
Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.
Sandra Ruiz García,Marie Deprez,Kevin Lebrigand,Amélie Cavard,Agnès Paquet,Marie-Jeanne Arguel,Virginie Magnone,Marin Truchi,Ignacio S. Caballero,Sylvie Leroy,Charles-Hugo Marquette,Brice Marcet,Pascal Barbry,Laure-Emmanuelle Zaragosi +13 more
TL;DR: Using single-cell transcriptomics and lineage inference, trajectories from basal to luminal cells are unraveled, providing novel markers for specific populations and offers new insights into the molecular mechanisms occurring during mucociliary epithelium regeneration.
Journal ArticleDOI
Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease
TL;DR: This review emphasizes established and recent discoveries that underline the central role of ASM and sets the stage for future research toward understanding how ASM plays a central role by being both upstream and downstream in the many interactive processes that determine airway structure and function in health and disease.
Journal ArticleDOI
More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis.
Andreas Frey,Lars Lunding,Johanna C. Ehlers,Markus Weckmann,Ulrich M. Zissler,Michael Wegmann +5 more
TL;DR: The airway epithelium is in the center of processes that lead to formation, progression and acute exacerbation of asthma, because its multiple abilities directly have an impact on the inflammatory response and thus the formation of the disease.
References
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Journal ArticleDOI
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,Christophe Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Silva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,Betsy Layton,Bruce Beutler +13 more
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
Alexander Poltorak,Xiaolong He,Irina Smirnova,Mu Ya Liu,C. Van Huffel,Xin Du,Dale Birdwell,E. Alejos,M. Suva,Chris Galanos,Marina Freudenberg,Paola Ricciardi-Castagnoli,B. Layton,Bruce Beutler +13 more
Journal ArticleDOI
A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
Journal ArticleDOI
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
Journal ArticleDOI
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
Florian Heil,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Carsten J. Kirschning,Shizuo Akira,Grayson B. Lipford,Hermann Wagner,Stefan Bauer +8 more
TL;DR: It is shown that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus–1 (HIV-1) stimulate dendritic cells and macrophages to secrete interferon-α and proinflammatory, as well as regulatory, cytokines, and these data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8.
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Defective epithelial barrier function in asthma.
Chang Xiao,Sarah M. Puddicombe,Sarah A. Field,Joel Haywood,Victoria Broughton-Head,Ilaria Puxeddu,Hans Michael Haitchi,Elizabeth Vernon-Wilson,David Sammut,Nicole Bedke,Catherine Cremin,Jody Sones,Ratko Djukanovic,Peter H. Howarth,Jane E. Collins,Stephen T. Holgate,Phillip Monk,Donna E. Davies +17 more