Journal ArticleDOI
Cancer immunotherapy – revisited
TLDR
The recent positive results of clinical trials with novel immunoactive drugs as well as the unexpected finding of a positive interaction between immunotherapy and chemotherapy may herald a new era for the immunotherapy of cancer.Abstract:
Our insight into antitumour immune responses has increased considerably during the past decades, yet the development of immunotherapy as a treatment modality for cancer has been hampered by several factors. These include difficulties in the selection of the optimal dose and schedule, the methods of evaluation, and financial support. Although durable clinical remissions have been observed with various immunotherapeutic strategies, the percentage of patients who benefited from these interventions has remained too small to justify the general use of such strategies. However, the recent positive results of clinical trials with novel immunoactive drugs as well as the unexpected finding of a positive interaction between immunotherapy and chemotherapy may herald a new era for the immunotherapy of cancer.read more
Citations
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Perspectives on Oncolytic Salmonella in Cancer Immunotherapy-A Promising Strategy
TL;DR: In this paper, the authors summarized the currently available data on the antitumor effects of Salmonella, and discussed a possibility of integrating salmonella into cancer immunotherapy to overcome current obstacles.
Journal ArticleDOI
Neoantigen-reactive T cells exhibit effective anti-tumor activity against colorectal cancer.
Yaojun Yu,Jing Zhang,Le-Yi Ni,Yue-Sheng Zhu,Hejie Yu,Yangyang Teng,Limiao Lin,Zhan-Xiong Xue,Xiangyang Xue,Xian Shen,Haiping Song,Su Xiaoping,Weihong Sun,Zhenzhai Cai +13 more
TL;DR: In this paper, the effectiveness and safety of neoantigen-based immunotherapies in patients with colorectal cancer (CRC), particularly in the Chin...Neoantigens play a crucial role in cancer immunotherapy.
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Adaptable peptide-based therapeutics modulating tumor microenvironment for combinatorial radio-immunotherapy.
Mingming Li,Zhongyan Wang,Xin Liu,Na Song,Yanqiu Song,Xuefeng Shi,Jinjian Liu,Jianfeng Liu,Zhilin Yu +8 more
TL;DR: In this article, a peptide-based approach was proposed for combinatorial radio-immunotherapy through simultaneous checkpoint blocking and induction of immunogenic cell death by co-assembling a pentapeptide containing a 4-amino proline residue with its derivatives containing IDO-1 inhibitor NLG919.
Journal ArticleDOI
Dendrimers for cancer immunotherapy: Avidity-based drug delivery vehicles for effective anti-tumor immune response.
Piper A Rawding,Jiyoon Bu,Jianxin Wang,Da Won Kim,Adam J. Drelich,Young-Soo Kim,Seungpyo Hong +6 more
TL;DR: A comprehensive overview of dendrimer-based immunotherapy technologies, including their formulations, biological functionalities, and therapeutic applications, can be found in this paper, where the authors also provide a critical overview on rapidly growing DNB-based Immunotherapy technologies and serve as a guideline for researchers and clinicians interested in this field.
Journal ArticleDOI
Cancer Risk in the Heart Failure Population: Epidemiology, Mechanisms, and Clinical Implications
Alessandra Cuomo,Flora Pirozzi,Umberto Attanasio,Riccardo Franco,Francesco Elia,Eliana De Rosa,Michele Russo,Alessandra Ghigo,Pietro Ameri,Carlo G. Tocchetti,Valentina Mercurio +10 more
TL;DR: This review aims at showing recent discoveries concerning new-onset cancer in HF patients, especially due to the limited therapeutic options for patients affected by both cancer and HF and the higher risk of cardiotoxicity from anticancer drugs.
References
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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
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TL;DR: Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation in a phase 3 randomized clinical trial.
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A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
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