Journal ArticleDOI
Cancer immunotherapy – revisited
TLDR
The recent positive results of clinical trials with novel immunoactive drugs as well as the unexpected finding of a positive interaction between immunotherapy and chemotherapy may herald a new era for the immunotherapy of cancer.Abstract:
Our insight into antitumour immune responses has increased considerably during the past decades, yet the development of immunotherapy as a treatment modality for cancer has been hampered by several factors. These include difficulties in the selection of the optimal dose and schedule, the methods of evaluation, and financial support. Although durable clinical remissions have been observed with various immunotherapeutic strategies, the percentage of patients who benefited from these interventions has remained too small to justify the general use of such strategies. However, the recent positive results of clinical trials with novel immunoactive drugs as well as the unexpected finding of a positive interaction between immunotherapy and chemotherapy may herald a new era for the immunotherapy of cancer.read more
Citations
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In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model
Joana M. Silva,Eva Zupancic,Gaëlle Vandermeulen,Vanessa G. Oliveira,Ana Salgado,Mafalda Videira,Manuela Gaspar,Luis Graca,Véronique Préat,Helena F. Florindo +9 more
TL;DR: It is demonstrated that the multifunctional properties of NPs in terms of targeting and antigen/adjuvant delivery have high cancer immunotherapeutic potential.
Journal ArticleDOI
Expression of VISTA correlated with immunosuppression and synergized with CD8 to predict survival in human oral squamous cell carcinoma
Lei Wu,Wei-Wei Deng,Cong-Fa Huang,Lin-Lin Bu,Guang-Tao Yu,Liang Mao,Wen-Feng Zhang,Bing Liu,Zhi-Jun Sun +8 more
TL;DR: Results indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment, and indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC.
Journal ArticleDOI
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway.
TL;DR: An updated review on the latest progress on the development of small molecule modulators targeting the cGAS‒STING‒TBK1 signaling pathway and their preclinical and clinical use as a new immune stimulatory therapy is provided.
Journal ArticleDOI
An aluminum adjuvant-integrated nano-MOF as antigen delivery system to induce strong humoral and cellular immune responses.
Xiaofang Zhong,Yunting Zhang,Lu Tan,Tao Zheng,Y.P. Hou,Xiaoyu Hong,Guangsheng Du,Xiao Yan Chen,Yuandong Zhang,Xun Sun +9 more
TL;DR: It is demonstrated that ZANPs may be a safe and effective vehicle for the development of cancer vaccines by taking advantage of a natural biomineralization process to create aluminum-containing nanoZIF-8 particles for antigen delivery.
Journal ArticleDOI
Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer
Michal Podrazil,Rudolf Horvath,Etienne Becht,Daniela Rozkova,Pavla Bilkova,Klara Sochorova,Hana Hromadkova,Jana Kayserova,Katerina Vavrova,Jan Lastovicka,Petra Vrabcova,Katerina Kubackova,Zdenka Gasova,Ladislav Jarolím,Marek Babjuk,Radek Spisek,Jirina Bartunkova,Jitka Fucikova +17 more
TL;DR: The combined chemoimmunotherapy with DCVAC/PCa and docetaxel was safe and resulted in longer than expected survival and any immunological parameter was not identified that significantly correlated with better OS.
References
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Journal ArticleDOI
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
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Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
Paul B. Chapman,Axel Hauschild,Caroline Robert,John B. A. G. Haanen,Paolo A. Ascierto,James Larkin,Reinhard Dummer,Claus Garbe,Alessandro Testori,Michele Maio,David W. Hogg,Paul Lorigan,Céleste Lebbé,Thomas Jouary,Dirk Schadendorf,Antoni Ribas,Jeffrey A. Sosman,John M. Kirkwood,Brigitte Dréno,K. B. Nolop,Jiang Li,B. Nelson,Jeannie Hou,Richard J. Lee,Keith T. Flaherty,Grant A. McArthur +25 more
TL;DR: Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation in a phase 3 randomized clinical trial.
Journal ArticleDOI
A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
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