Journal ArticleDOI
Cancer immunotherapy – revisited
TLDR
The recent positive results of clinical trials with novel immunoactive drugs as well as the unexpected finding of a positive interaction between immunotherapy and chemotherapy may herald a new era for the immunotherapy of cancer.Abstract:
Our insight into antitumour immune responses has increased considerably during the past decades, yet the development of immunotherapy as a treatment modality for cancer has been hampered by several factors. These include difficulties in the selection of the optimal dose and schedule, the methods of evaluation, and financial support. Although durable clinical remissions have been observed with various immunotherapeutic strategies, the percentage of patients who benefited from these interventions has remained too small to justify the general use of such strategies. However, the recent positive results of clinical trials with novel immunoactive drugs as well as the unexpected finding of a positive interaction between immunotherapy and chemotherapy may herald a new era for the immunotherapy of cancer.read more
Citations
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The secret ally: immunostimulation by anticancer drugs
TL;DR: The molecular and cellular circuitries whereby cytotoxic agents can activate the immune system against cancer, and their therapeutic implications, are discussed.
Journal ArticleDOI
Turning the corner on therapeutic cancer vaccines
TL;DR: Key steps are highlighted that are bringing the promise of therapeutic cancer vaccines within reach, including learning which vaccine approaches elicit the potent, balanced, and durable CD4 plus CD8 T cell expansion necessary for clinical efficacy.
Journal ArticleDOI
Classification of current anticancer immunotherapies
Lorenzo Galluzzi,Erika Vacchelli,José Manuel Bravo-San Pedro,Aitziber Buqué,Laura Senovilla,Elisa E. Baracco,Norma Bloy,Francesca Castoldi,Jean Pierre Abastado,Patrizia Agostinis,Ron N. Apte,Fernando Aranda,Maha Ayyoub,Philipp Beckhove,Jean-Yves Blay,Laura Bracci,Anne Caignard,Chiara Castelli,Federica Cavallo,Estaban Celis,Vincenzo Cerundolo,Aled Clayton,Mario P. Colombo,Lisa M. Coussens,Madhav V. Dhodapkar,Alexander M.M. Eggermont,Douglas T. Fearon,Wolf H. Fridman,Jitka Fucikova,Dmitry I. Gabrilovich,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,François Ghiringhelli,Giuseppe Giaccone,Giuseppe Giaccone,Eli Gilboa,Sacha Gnjatic,Axel Hoos,Anne Hosmalin,Anne Hosmalin,Anne Hosmalin,Dirk Jäger,Pawel Kalinski,Klas Kärre,Oliver Kepp,Rolf Kiessling,John M. Kirkwood,Eva Klein,Alexander Knuth,Claire E. Lewis,Roland S. Liblau,Roland S. Liblau,Roland S. Liblau,Michael T. Lotze,Enrico Lugli,Jean-Pierre Mach,Fabrizio Mattei,Domenico Mavilio,Ignacio Melero,Cornelis J. M. Melief,E. A. Mittendorf,Lorenzo Moretta,Adekunke Odunsi,Hideho Okada,Anna Karolina Palucka,Marcus E. Peter,Kenneth J. Pienta,Angel Porgador,George C. Prendergast,George C. Prendergast,Gabriel A. Rabinovich,Nicholas P. Restifo,Naiyer A. Rizvi,Catherine Sautès-Fridman,Hans Schreiber,Barbara Seliger,Hiroshi Shiku,Bruno Silva-Santos,Mark J. Smyth,Mark J. Smyth,Daniel E. Speiser,Daniel E. Speiser,Radek Spisek,Pramod K. Srivastava,James E. Talmadge,Eric Tartour,Sjoerd H. van der Burg,Benoît Van den Eynde,Benoît Van den Eynde,Richard G. Vile,Hermann Wagner,Jeffrey S. Weber,Theresa L. Whiteside,Jedd D. Wolchok,Jedd D. Wolchok,Laurence Zitvogel,Weiping Zou,Guido Kroemer +98 more
TL;DR: A critical, integrated classification of anticancer immunotherapies is proposed and the clinical relevance of these approaches is discussed.
Journal ArticleDOI
Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
Laurie Menger,Erika Vacchelli,Erika Vacchelli,Erika Vacchelli,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Isabelle Martins,Isabelle Martins,Isabelle Martins,Yuting Ma,Yuting Ma,Yuting Ma,Shensi Shen,Shensi Shen,Shensi Shen,Takahiro Yamazaki,Takahiro Yamazaki,Takahiro Yamazaki,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Grégoire Mignot,Frédéric Schlemmer,Frédéric Schlemmer,Frédéric Schlemmer,Eric Sulpice,Clara Locher,Clara Locher,Clara Locher,Xavier Gidrol,François Ghiringhelli,Nazanine Modjtahedi,Nazanine Modjtahedi,Nazanine Modjtahedi,Lorenzo Galluzzi,Lorenzo Galluzzi,Fabrice Andre,Fabrice Andre,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Oliver Kepp,Oliver Kepp,Oliver Kepp,Guido Kroemer +48 more
TL;DR: Rec retrospective clinical analyses revealed that the administration of the CG digoxin during chemotherapy had a positive impact on overall survival in cohorts of breast, colorectal, head and neck, and hepatocellular carcinoma patients, especially when they were treated with agents other than anthracyclines and oxaliplatin.
Journal ArticleDOI
Molecular Pathways: The Immunogenic Effects of Platinum-Based Chemotherapeutics
TL;DR: The literature on the immunogenic effects of platinum is reviewed, the clinical advances using platinum as a cytotoxic compound with immune adjuvant properties are summarized, the limitations to these studies are discussed, and the gaps in the understanding of the immunologic effects of these drugs are discussed.
References
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Journal ArticleDOI
Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration.
Laura Bracci,Federica Moschella,Paola Sestili,Valentina La Sorsa,Mara Valentini,Irene Canini,Sara Baccarini,Sonia Maccari,Carlo Ramoni,Filippo Belardelli,Enrico Proietti +10 more
TL;DR: The ensemble of these data provides a new rationale for combining immunotherapy and chemotherapy to induce an effective antitumor response in cancer patients.
Journal ArticleDOI
Ipilimumab: controversies in its development, utility and autoimmune adverse events
TL;DR: Favorable survival in patients with stage IV melanoma were observed that appear to be associated with unique side effects of the drug called “immune-related adverse events”, and the unusual kinetics of anti-tumor response with ipilimumab are described.
Journal ArticleDOI
Vaccination With Patient-Specific Tumor-Derived Antigen in First Remission Improves Disease-Free Survival in Follicular Lymphoma
Stephen J. Schuster,Sattva S. Neelapu,Barry L. Gause,John E. Janik,Franco M. Muggia,Jon P. Gockerman,Jane N. Winter,Christopher R. Flowers,Daniel A. Nikcevich,Eduardo M. Sotomayor,Dean S. McGaughey,Elaine S. Jaffe,Elise A. Chong,Craig W. Reynolds,Donald A. Berry,Carlos F. Santos,Mihaela A. Popa,Amy M. McCord,Larry W. Kwak +18 more
TL;DR: Vaccination with patient-specific hybridoma-derived Id vaccine after chemotherapy-induced CR/CRu may prolong DFS in patients with FL and vaccine isotype may affect clinical outcome and explain differing results between this and other controlled Id-vaccine trials.
Journal Article
Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide.
TL;DR: It is suggested that a B-lymphocyte response to soluble antigen modulates a normal cell-mediated immune response during the development of chemical contact sensitivity in the healthy animal and that this could be blocked completely by treatment with CY prior to sensitization or partially by splenectomy after sensitization.
Journal ArticleDOI
Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients
Joannes F M Jacobs,Cornelis J. A. Punt,W. Joost Lesterhuis,Roger P.M. Sutmuller,H. Mary-lène H. Brouwer,Nicole M. Scharenborg,Ina S. Klasen,Luuk B. Hilbrands,Carl G. Figdor,I. Jolanda M. de Vries,Gosse J. Adema +10 more
TL;DR: The results indicate that for immunotherapeutic benefit of transient Treg depletion, timing and dosing as well as Treg specificity are extremely important.
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