Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.
Victoria A. Avanzato,Victoria A. Avanzato,M. Jeremiah Matson,M. Jeremiah Matson,Stephanie N. Seifert,Rhys Pryce,Brandi N. Williamson,Sarah L. Anzick,Kent D. Barbian,Seth D. Judson,Elizabeth R. Fischer,Craig Martens,Thomas A. Bowden,Emmie de Wit,Francis X. Riedo,Vincent J. Munster +15 more
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TLDR
The data indicate that certain immunocompromised patients may shed infectious virus for longer durations than previously recognized, and detection of subgenomic RNA is recommended in persistently SARS-CoV-2 positive individuals as a proxy for shedding of infectious virus.About:
This article is published in Cell.The article was published on 2020-12-23 and is currently open access. It has received 573 citations till now.read more
Citations
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Three-dose mRNA-1273 vaccination schedule: sufficient antibody response in majority of immunocompromised hematology patients
Sabine Haggenburg,Quincy Hofsink,Birgit I. Lissenberg-Witte,Anna Elisabeth Clasine Broers,Jaap van Doesum,Rob van Binnendijk,Gerco den Hartog,M. Bhoekhan,Nienke J. E. Haverkate,Judith A. Burger,J. H. Bouhuijs,Gaby Smits,D. Wouters,Ester M. M. van Leeuwen,H J Bontkes,N. Kootstra,Sonja Zweegman,A.P. Kater,M.H.M. Heemskerk,Kevin Groen,Tom van Meerten,Pim G N J Mutsaers,Tim Beaumont,Marit J. van Gils,Abraham Goorhuis,Caroline E. Rutten,Mette D. Hazenberg,Inger S. Nijhof +27 more
TL;DR: The primary schedule for immunocompromised patients with hematologic malignancies should be supplemented with a delayed 3rd vaccination.
Prolonged Viral Shedding in Three Young Adult Cases of COVID-19
TL;DR: It is reported that three young adult cases of COVID-19 patients, who were either immunosuppressed nor severe, showed prolonged viral RNA shedding from the upper respiratory tract for 58, 81, and 137 days since initial diagnosis, which is the longest duration of viral shedding reported to date in young adult patients.
Journal ArticleDOI
The origins of new SARS-COV-2 variants in immunocompromised individuals
TL;DR: In this article , the origins of new severe acute respiratory coronavirus 2 (SARS-CoV-2) variants in immunocompromised individuals and whether the emergence of novel mutations in these individuals is responsible for the development of variants of concern (VOC).
Journal ArticleDOI
Surgery for Cancer in the Wake of Second and Future Waves! Challenges and Opportunities in the Indian Context.
TL;DR: In this article, a review article focusing on the current challenges and the ways to mitigate them is presented, which is important in ensuring continuity of care for cancer patients as well as to limit the consequences of one getting infected with the COVID-19.
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Long-term asymptomatic SARS-CoV-2 infection associated with deficiency on multiple immune cells
Gang He,Xia Chuai,D. Liang,Chunyu Chen,Chang-zheng Hu,Changwen Ke,Bixia Ke,Peilin Zhen,Huajun Zhang +8 more
TL;DR: The immune responses and function of immune cells among asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cases, especially in immuno-compromised individuals, remain largely unknown as discussed by the authors .
References
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The Sequence Alignment/Map format and SAMtools
Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
TL;DR: SAMtools as discussed by the authors implements various utilities for post-processing alignments in the SAM format, such as indexing, variant caller and alignment viewer, and thus provides universal tools for processing read alignments.
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Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
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MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Kazutaka Katoh,Daron M. Standley +1 more
TL;DR: This version of MAFFT has several new features, including options for adding unaligned sequences into an existing alignment, adjustment of direction in nucleotide alignment, constrained alignment and parallel processing, which were implemented after the previous major update.
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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
Aaron McKenna,Matthew Hanna,Eric Banks,Andrey Sivachenko,Kristian Cibulskis,Andrew Kernytsky,Kiran V. Garimella,David Altshuler,Stacey Gabriel,Mark J. Daly,Mark A. DePristo +10 more
TL;DR: The GATK programming framework enables developers and analysts to quickly and easily write efficient and robust NGS tools, many of which have already been incorporated into large-scale sequencing projects like the 1000 Genomes Project and The Cancer Genome Atlas.
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Cutadapt removes adapter sequences from high-throughput sequencing reads
TL;DR: The command-line tool cutadapt is developed, which supports 454, Illumina and SOLiD (color space) data, offers two adapter trimming algorithms, and has other useful features.
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